0000950123-21-006686.txt : 20210517 0000950123-21-006686.hdr.sgml : 20210517 20210517064519 ACCESSION NUMBER: 0000950123-21-006686 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20210331 FILED AS OF DATE: 20210517 DATE AS OF CHANGE: 20210517 EFFECTIVENESS DATE: 20210517 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PICTET ASSET MANAGEMENT LTD CENTRAL INDEX KEY: 0001291274 IRS NUMBER: 000000000 STATE OF INCORPORATION: X0 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-11664 FILM NUMBER: 21927422 BUSINESS ADDRESS: STREET 1: MOOR HOUSE, LEVEL 11 STREET 2: 120 LONDON WALL CITY: LONDON STATE: X0 ZIP: EC2Y 5ET BUSINESS PHONE: 44 207 847 5000 MAIL ADDRESS: STREET 1: MOOR HOUSE, LEVEL 11 STREET 2: 120 LONDON WALL CITY: LONDON STATE: X0 ZIP: EC2Y 5ET FORMER COMPANY: FORMER CONFORMED NAME: PICTET INTERNATIONAL MANAGEMENT LTD DATE OF NAME CHANGE: 20040521 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001291274 XXXXXXXX 03-31-2021 03-31-2021 false PICTET ASSET MANAGEMENT LTD

MOOR HOUSE, LEVEL 11 120 LONDON WALL LONDON X0 EC2Y 5ET

13F HOLDINGS REPORT 028-11664 N David Cawthrow 00 44 207 847 5040 David Cawthrow London X0 05-11-2021 2 2752 83221419 false 1 28-11884 Pictet Asset Management SA 2 Pictet Asset Management Europe SA INFORMATION TABLE 2 4454.xml INFORMATION TABLE FOR FORM 13F 10X GENOMICS INC CL A COM 88025U109 17083 94383 SH DFND 0 0 0 10X GENOMICS INC CL A COM 88025U109 10566 58375 SH DFND 1 0 0 21VIANET GROUP INC SPONSORED ADS A 90138A103 75208 2328419 SH DFND 0 0 0 2U INC COM 90214J101 13756 359815 SH DFND 0 0 0 360 DIGITECH INC AMERICAN DEP 88557W101 879 33800 SH DFND 0 0 0 3-D SYS CORP DEL COM NEW 88554D205 288 10500 SH DFND 0 0 0 3M CO COM 88579Y101 161407 837698 SH DFND 0 0 0 3M CO COM 88579Y101 16927 87848 SH DFND 1 0 0 51JOB INC SPONSORED ADS 316827104 2272 36300 SH DFND 0 0 0 51JOB INC SPONSORED ADS 316827104 291 4641 SH DFND 1 0 0 8X8 INC NEW COM 282914100 247 7600 SH DFND 0 0 0 AAON INC COM PAR $0.004 000360206 224 3200 SH DFND 0 0 0 ABBOTT LABS COM 002824100 185709 1549637 SH DFND 0 0 0 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668 12200 SH DFND 0 0 0 CIGNA CORP NEW COM 125523100 35758 147920 SH DFND 0 0 0 CIGNA CORP NEW COM 125523100 6036 24967 SH DFND 1 0 0 CIMAREX ENERGY CO COM 171798101 463 7800 SH DFND 0 0 0 CINCINNATI FINL CORP COM 172062101 6464 62705 SH DFND 0 0 0 CINCINNATI FINL CORP COM 172062101 953 9242 SH DFND 1 0 0 CINEMARK HLDGS INC COM 17243V102 208 10200 SH DFND 0 0 0 CINTAS CORP COM 172908105 117063 342980 SH DFND 0 0 0 CINTAS CORP COM 172908105 2153 6309 SH DFND 1 0 0 CIRRUS LOGIC INC COM 172755100 339 4000 SH DFND 0 0 0 CISCO SYS INC COM 17275R102 250542 4845138 SH DFND 0 0 0 CISCO SYS INC COM 17275R102 25438 491931 SH DFND 1 0 0 CIT GROUP INC COM NEW 125581801 366 7100 SH DFND 0 0 0 CITIGROUP INC COM NEW 172967424 81180 1115883 SH DFND 0 0 0 CITIGROUP INC COM NEW 172967424 19712 270952 SH DFND 1 0 0 CITIZENS FINANCIAL GROUP INC COM 174610105 8144 184465 SH DFND 0 0 0 CITIZENS FINANCIAL GROUP INC COM 174610105 1258 28500 SH DFND 1 0 0 CITRIX SYS INC COM 177376100 186577 1329277 SH DFND 0 0 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CORP COM 125896100 1053 17200 SH DFND 1 0 0 CNH INDL N V SHS N20944109 8925 575525 SH DFND 0 0 0 CNH INDL N V SHS N20944109 1167 75218 SH DFND 1 0 0 CNO FINL GROUP INC COM 12621E103 274 11300 SH DFND 0 0 0 CNX RES CORP COM 12653C108 256 17400 SH DFND 0 0 0 COCA COLA CO COM 191216100 109106 2069931 SH DFND 0 0 0 COCA COLA CO COM 191216100 15758 298956 SH DFND 1 0 0 COCA COLA EUROPEAN PARTNERS SHS G25839104 5883 113243 SH DFND 0 0 0 COCA COLA EUROPEAN PARTNERS SHS G25839104 1168 22484 SH DFND 1 0 0 COEUR MNG INC COM NEW 192108504 158 17500 SH DFND 0 0 0 COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 241 3500 SH DFND 0 0 0 COGNEX CORP COM 192422103 100030 1205326 SH DFND 0 0 0 COGNEX CORP COM 192422103 830 10000 SH DFND 1 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 52270 669096 SH DFND 0 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 5840 74762 SH DFND 1 0 0 COHERENT INC COM 192479103 800 3162 SH DFND 0 0 0 COHERUS BIOSCIENCES INC COM 19249H103 2622 179438 SH DFND 0 0 0 COLFAX CORP COM 194014106 355 8100 SH DFND 0 0 0 COLGATE PALMOLIVE CO COM 194162103 34226 434173 SH DFND 0 0 0 COLGATE PALMOLIVE CO COM 194162103 15861 201209 SH DFND 1 0 0 COLLIERS INTL GROUP INC SUB VTG SHS 194693107 255 2600 SH DFND 0 0 0 COLONY CAP INC NEW CL A COM 19626G108 200 30800 SH DFND 0 0 0 COLONY CAP INC NEW CL A COM 19626G108 440 68000 SH DFND 1 0 0 COLUMBIA BKG SYS INC COM 197236102 233 5400 SH DFND 0 0 0 COLUMBIA PPTY TR INC COM NEW 198287203 171 10000 SH DFND 0 0 0 COLUMBIA PPTY TR INC COM NEW 198287203 267 15600 SH DFND 1 0 0 COLUMBIA SPORTSWEAR CO COM 198516106 26767 253408 SH DFND 0 0 0 COMCAST CORP NEW CL A 20030N101 438214 8098574 SH DFND 0 0 0 COMCAST CORP NEW CL A 20030N101 57161 1056394 SH DFND 1 0 0 COMERICA INC COM 200340107 1399 19500 SH DFND 0 0 0 COMFORT SYS USA INC COM 199908104 224 3000 SH DFND 0 0 0 COMMERCE BANCSHARES INC COM 200525103 616 8045 SH DFND 0 0 0 COMMERCIAL METALS CO COM 201723103 318 10300 SH DFND 0 0 0 COMMSCOPE HLDG CO INC COM 20337X109 218 14200 SH DFND 0 0 0 COMMUNITY BK SYS INC COM 203607106 307 4000 SH DFND 0 0 0 COMMUNITY HEALTHCARE TR INC COM 20369C106 64 1392 SH DFND 0 0 0 COMMUNITY HEALTHCARE TR INC COM 20369C106 143 3093 SH DFND 1 0 0 COMMVAULT SYSTEMS INC COM 204166102 226 3500 SH DFND 0 0 0 COMPANHIA DE SANEAMENTO BASI SPONSORED ADR 20441A102 1792 245419 SH DFND 0 0 0 COMPANIA DE MINAS BUENAVENTU SPONSORED ADR 204448104 4029 409459 SH DFND 0 0 0 CONAGRA BRANDS INC COM 205887102 6548 174162 SH DFND 0 0 0 CONAGRA BRANDS INC COM 205887102 1224 32550 SH DFND 1 0 0 CONCENTRIX CORP COM 20602D101 449 3000 SH DFND 0 0 0 CONMED CORP COM 207410101 287 2200 SH DFND 0 0 0 CONOCOPHILLIPS COM 20825C104 28311 534475 SH DFND 0 0 0 CONOCOPHILLIPS COM 20825C104 13477 254424 SH DFND 1 0 0 CONSOLIDATED EDISON INC COM 209115104 11535 154211 SH DFND 0 0 0 CONSOLIDATED EDISON INC COM 209115104 1651 22074 SH DFND 1 0 0 CONSTELLATION BRANDS INC CL A 21036P108 16179 70961 SH DFND 0 0 0 CONSTELLATION BRANDS INC CL A 21036P108 2554 11200 SH DFND 1 0 0 COOPER COS INC COM NEW 216648402 61072 159003 SH DFND 0 0 0 COOPER COS INC COM NEW 216648402 1371 3570 SH DFND 1 0 0 COOPER TIRE & RUBR CO COM 216831107 224 4000 SH DFND 0 0 0 COPART INC COM 217204106 9612 88500 SH DFND 0 0 0 COPART INC COM 217204106 1455 13400 SH DFND 1 0 0 CORELOGIC INC COM 21871D103 468 5900 SH DFND 0 0 0 CORESITE RLTY CORP COM 21870Q105 384 3200 SH DFND 0 0 0 CORNING INC COM 219350105 12522 287807 SH DFND 0 0 0 CORNING INC COM 219350105 2916 67019 SH DFND 1 0 0 CORPORATE OFFICE PPTYS TR SH BEN INT 22002T108 229 8700 SH DFND 0 0 0 CORPORATE OFFICE PPTYS TR SH BEN INT 22002T108 421 16000 SH DFND 1 0 0 CORTEVA INC COM 22052L104 12420 266421 SH DFND 0 0 0 CORTEVA INC COM 22052L104 2523 54111 SH DFND 1 0 0 COSTAR GROUP INC COM 22160N109 9510 11571 SH DFND 0 0 0 COSTAR GROUP INC COM 22160N109 2121 2580 SH DFND 1 0 0 COSTCO WHSL CORP NEW COM 22160K105 66698 189224 SH DFND 0 0 0 COSTCO WHSL CORP NEW COM 22160K105 10571 29990 SH DFND 1 0 0 COTY INC COM CL A 222070203 242 26900 SH DFND 0 0 0 COUPA SOFTWARE INC COM 22266L106 5039 19801 SH DFND 0 0 0 COUPA SOFTWARE INC COM 22266L106 1145 4500 SH DFND 1 0 0 COUPANG INC CL A 22266T109 27338 553965 SH DFND 0 0 0 COUSINS PPTYS INC COM NEW 222795502 417 11800 SH DFND 0 0 0 COUSINS PPTYS INC COM NEW 222795502 752 21273 SH DFND 1 0 0 COVETRUS INC COM 22304C100 268 8937 SH DFND 0 0 0 CRACKER BARREL OLD CTRY STOR COM 22410J106 311 1800 SH DFND 0 0 0 CRANE CO COM 224399105 272 2900 SH DFND 0 0 0 CREDICORP LTD COM G2519Y108 9967 72984 SH DFND 0 0 0 CREDIT ACCEP CORP MICH COM 225310101 292 810 SH DFND 0 0 0 CREE INC COM 225447101 176398 1631349 SH DFND 0 0 0 CREE INC COM 225447101 386 3571 SH DFND 1 0 0 CRESCENT PT ENERGY CORP COM 22576C101 156 37300 SH DFND 0 0 0 CRISPR THERAPEUTICS AG NAMEN AKT H17182108 548 4500 SH DFND 0 0 0 CROCS INC COM 227046109 410 5100 SH DFND 0 0 0 CRONOS GROUP INC COM 22717L101 116 12300 SH DFND 0 0 0 CROWDSTRIKE HLDGS INC CL A 22788C105 113916 624162 SH DFND 0 0 0 CROWDSTRIKE HLDGS INC CL A 22788C105 2129 11666 SH DFND 1 0 0 CROWN CASTLE INTL CORP NEW COM 22822V101 302315 1756315 SH DFND 0 0 0 CROWN CASTLE INTL CORP NEW COM 22822V101 4923 28602 SH DFND 1 0 0 CROWN HLDGS INC COM 228368106 3797 39121 SH DFND 0 0 0 CROWN HLDGS INC COM 228368106 907 9350 SH DFND 1 0 0 CSX CORP COM 126408103 37166 385454 SH DFND 0 0 0 CSX CORP COM 126408103 5086 52750 SH DFND 1 0 0 CUBESMART COM 229663109 586 15500 SH DFND 0 0 0 CUBESMART COM 229663109 1048 27700 SH DFND 1 0 0 CULLEN FROST BANKERS INC COM 229899109 457 4200 SH DFND 0 0 0 CUMMINS INC COM 231021106 30214 116609 SH DFND 0 0 0 CUMMINS INC COM 231021106 3251 12545 SH DFND 1 0 0 CURTISS WRIGHT CORP COM 231561101 391 3300 SH DFND 0 0 0 CVB FINL CORP COM 126600105 254 11500 SH DFND 0 0 0 CVS HEALTH CORP COM 126650100 35722 474840 SH DFND 0 0 0 CVS HEALTH CORP COM 126650100 6451 85744 SH DFND 1 0 0 CYBERARK SOFTWARE LTD SHS M2682V108 66145 511403 SH DFND 0 0 0 CYBERARK SOFTWARE LTD SHS M2682V108 319 2470 SH DFND 1 0 0 CYRUSONE INC COM 23283R100 19394 286384 SH DFND 0 0 0 CYRUSONE INC COM 23283R100 1158 17100 SH DFND 1 0 0 CYTOKINETICS INC COM NEW 23282W605 7056 303346 SH DFND 0 0 0 CYTOKINETICS INC COM NEW 23282W605 2710 116507 SH DFND 1 0 0 D R HORTON INC COM 23331A109 96513 1082957 SH DFND 0 0 0 D R HORTON INC COM 23331A109 20319 227996 SH DFND 1 0 0 DANA INC COM 235825205 251 10300 SH DFND 0 0 0 DANAHER CORPORATION COM 235851102 797783 3544442 SH DFND 0 0 0 DANAHER CORPORATION COM 235851102 27077 120300 SH DFND 1 0 0 DAQO NEW ENERGY CORP SPNSRD ADS NEW 23703Q203 18095 239661 SH DFND 0 0 0 DAQO NEW ENERGY CORP SPNSRD ADS NEW 23703Q203 3493 46268 SH DFND 1 0 0 DARDEN RESTAURANTS INC COM 237194105 9769 68791 SH DFND 0 0 0 DARDEN RESTAURANTS INC COM 237194105 1664 11721 SH DFND 1 0 0 DARLING INGREDIENTS INC COM 237266101 50295 683548 SH DFND 0 0 0 DATADOG INC CL A COM 23804L103 4063 48761 SH DFND 0 0 0 DATADOG INC CL A COM 23804L103 936 11226 SH DFND 1 0 0 DAVITA INC COM 23918K108 3481 32306 SH DFND 0 0 0 DAVITA INC COM 23918K108 647 6000 SH DFND 1 0 0 DBX ETF TR XTRACK HRVST CSI 233051879 36043 933272 SH DFND 0 0 0 DBX ETF TR XTRACK HRVST CSI 233051879 11862 307150 SH DFND 1 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 24267 541186 SH DFND 0 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 8891 198295 SH DFND 1 0 0 DECKERS OUTDOOR CORP COM 243537107 694 2100 SH DFND 0 0 0 DEERE & CO COM 244199105 181345 484698 SH DFND 0 0 0 DEERE & CO COM 244199105 7838 20950 SH DFND 1 0 0 DELL TECHNOLOGIES INC CL C 24703L202 6206 70407 SH DFND 0 0 0 DELL TECHNOLOGIES INC CL C 24703L202 4898 55560 SH DFND 1 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 9412 194951 SH DFND 0 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 819 16969 SH DFND 1 0 0 DENALI THERAPEUTICS INC COM 24823R105 21098 369493 SH DFND 0 0 0 DENALI THERAPEUTICS INC COM 24823R105 6795 119006 SH DFND 1 0 0 DENTSPLY SIRONA INC COM 24906P109 5985 93793 SH DFND 0 0 0 DENTSPLY SIRONA INC COM 24906P109 1329 20835 SH DFND 1 0 0 DESCARTES SYS GROUP INC COM 249906108 500 8200 SH DFND 0 0 0 DESPEGAR COM CORP ORD SHS G27358103 284 20811 SH DFND 0 0 0 DEUTSCHE BANK A G NAMEN AKT D18190898 11749 981226 SH DFND 0 0 0 DEUTSCHE BANK A G NAMEN AKT D18190898 1830 152792 SH DFND 1 0 0 DEVON ENERGY CORP NEW COM 25179M103 4854 222162 SH DFND 0 0 0 DEVON ENERGY CORP NEW COM 25179M103 890 40727 SH DFND 1 0 0 DEXCOM INC COM 252131107 61958 172397 SH DFND 0 0 0 DEXCOM INC COM 252131107 2228 6200 SH DFND 1 0 0 DIAMONDBACK ENERGY INC COM 25278X109 2021 27500 SH DFND 0 0 0 DIAMONDROCK HOSPITALITY CO COM 252784301 156 15200 SH DFND 0 0 0 DIAMONDROCK HOSPITALITY CO COM 252784301 302 29300 SH DFND 1 0 0 DICKS SPORTING GOODS INC COM 253393102 388 5100 SH DFND 0 0 0 DIGITAL RLTY TR INC COM 253868103 230294 1635148 SH DFND 0 0 0 DIGITAL RLTY TR INC COM 253868103 8111 57587 SH DFND 1 0 0 DIGITAL TURBINE INC COM NEW 25400W102 482 6000 SH DFND 0 0 0 DIODES INC COM 254543101 255 3200 SH DFND 0 0 0 DISCOVER FINL SVCS COM 254709108 13279 139796 SH DFND 0 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256746108 10347 90398 SH DFND 0 0 0 DOLLAR TREE INC COM 256746108 1848 16148 SH DFND 1 0 0 DOMINION ENERGY INC COM 25746U109 447684 5893683 SH DFND 0 0 0 DOMINION ENERGY INC COM 25746U109 4056 53390 SH DFND 1 0 0 DOMINOS PIZZA INC COM 25754A201 8381 22789 SH DFND 0 0 0 DOMINOS PIZZA INC COM 25754A201 1542 4192 SH DFND 1 0 0 DOMTAR CORP COM NEW 257559203 21693 587112 SH DFND 0 0 0 DOMTAR CORP COM NEW 257559203 2358 63805 SH DFND 1 0 0 DONALDSON INC COM 257651109 10293 176969 SH DFND 0 0 0 DONALDSON INC COM 257651109 107 1846 SH DFND 1 0 0 DORMAN PRODS INC COM 258278100 226 2200 SH DFND 0 0 0 DOUGLAS EMMETT INC COM 25960P109 389 12400 SH DFND 0 0 0 DOUGLAS EMMETT INC COM 25960P109 738 23500 SH DFND 1 0 0 DOUYU INTL HLDGS LTD SPONSORED ADS 25985W105 1326 127400 SH DFND 0 0 0 DOVER CORP COM 260003108 8942 65208 SH DFND 0 0 0 DOVER CORP COM 260003108 1433 10450 SH DFND 1 0 0 DOW INC COM 260557103 17317 270839 SH DFND 0 0 0 DOW INC COM 260557103 3159 49401 SH DFND 1 0 0 DRAFTKINGS INC COM CL A 26142R104 2991 48774 SH DFND 0 0 0 DRAFTKINGS INC COM CL A 26142R104 1893 30863 SH DFND 1 0 0 DROPBOX INC CL A 26210C104 361400 13555888 SH DFND 0 0 0 DROPBOX INC CL A 26210C104 9106 341556 SH DFND 1 0 0 DTE ENERGY CO COM 233331107 95581 717898 SH DFND 0 0 0 DTE ENERGY CO COM 233331107 1678 12600 SH DFND 1 0 0 DUKE ENERGY CORP NEW COM NEW 26441C204 300604 3114103 SH DFND 0 0 0 DUKE ENERGY CORP NEW COM NEW 26441C204 4625 47908 SH DFND 1 0 0 DUKE REALTY CORP COM NEW 264411505 14798 352908 SH DFND 0 0 0 DUKE REALTY CORP COM NEW 264411505 3262 77800 SH DFND 1 0 0 DUPONT DE NEMOURS INC COM 26614N102 21358 276373 SH DFND 0 0 0 DUPONT DE NEMOURS INC COM 26614N102 4599 59507 SH DFND 1 0 0 DURECT CORP COM 266605104 27 13500 SH DFND 0 0 0 DXC TECHNOLOGY CO COM 23355L106 1083 34640 SH DFND 0 0 0 DYCOM INDS INC COM 267475101 260 2800 SH DFND 0 0 0 DYNATRACE INC COM NEW 268150109 2603 53973 SH DFND 0 0 0 DYNATRACE INC COM NEW 268150109 672 13927 SH DFND 1 0 0 EAGLE MATLS INC COM 26969P108 417 3100 SH DFND 0 0 0 EAGLE PHARMACEUTICALS INC COM 269796108 1407 33706 SH DFND 0 0 0 EAST WEST BANCORP INC COM 27579R104 790 10700 SH DFND 0 0 0 EASTERLY GOVT PPTYS INC COM 27616P103 118 5700 SH DFND 0 0 0 EASTERLY GOVT PPTYS INC COM 27616P103 241 11600 SH DFND 1 0 0 EASTGROUP PPTYS INC COM 277276101 473 3300 SH DFND 0 0 0 EASTGROUP PPTYS INC COM 277276101 788 5500 SH DFND 1 0 0 EASTMAN CHEM CO COM 277432100 5487 49830 SH DFND 0 0 0 EASTMAN CHEM CO COM 277432100 920 8350 SH DFND 1 0 0 EATON CORP PLC SHS G29183103 24569 177680 SH DFND 0 0 0 EATON CORP PLC SHS G29183103 3737 27023 SH DFND 1 0 0 EBAY INC. COM 278642103 215401 3517324 SH DFND 0 0 0 EBAY INC. COM 278642103 5287 86338 SH DFND 1 0 0 ECOLAB INC COM 278865100 719353 3360365 SH DFND 0 0 0 ECOLAB INC COM 278865100 20065 93730 SH DFND 1 0 0 EDISON INTL COM 281020107 238682 4073069 SH DFND 0 0 0 EDISON INTL COM 281020107 1465 25000 SH DFND 1 0 0 EDITAS MEDICINE INC COM 28106W103 210 5000 SH DFND 0 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 68682 821163 SH DFND 0 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 5236 62598 SH DFND 1 0 0 ELANCO ANIMAL HEALTH INC COM 28414H103 61271 2080525 SH DFND 0 0 0 ELANCO ANIMAL HEALTH INC COM 28414H103 801 27192 SH DFND 1 0 0 ELASTIC N V ORD SHS N14506104 512 4600 SH DFND 0 0 0 ELBIT SYS LTD ORD M3760D101 428 2997 SH DFND 0 0 0 ELBIT SYS LTD ORD M3760D101 72 502 SH DFND 1 0 0 ELDORADO GOLD CORP NEW COM 284902509 132 12200 SH DFND 0 0 0 ELECTRONIC ARTS INC COM 285512109 146891 1085107 SH DFND 0 0 0 ELECTRONIC ARTS INC COM 285512109 18717 138267 SH DFND 1 0 0 ELEMENT SOLUTIONS INC COM 28618M106 331 18100 SH DFND 0 0 0 EMCOR GROUP INC COM 29084Q100 449 4000 SH DFND 0 0 0 EMERGENT BIOSOLUTIONS INC COM 29089Q105 316 3400 SH DFND 0 0 0 EMERGENT BIOSOLUTIONS INC COM 29089Q105 5881 63303 SH DFND 1 0 0 EMERSON ELEC CO COM 291011104 33400 370213 SH DFND 0 0 0 EMERSON ELEC CO COM 291011104 4190 46437 SH DFND 1 0 0 EMPIRE ST RLTY TR INC CL A 292104106 105 9400 SH DFND 0 0 0 EMPIRE ST RLTY TR INC CL A 292104106 240 21600 SH DFND 1 0 0 ENANTA PHARMACEUTICALS INC COM 29251M106 1519 30806 SH DFND 0 0 0 ENBRIDGE INC COM 29250N105 27735 761435 SH DFND 0 0 0 ENBRIDGE INC COM 29250N105 4835 132735 SH DFND 1 0 0 ENCOMPASS HEALTH CORP COM 29261A100 639 7800 SH DFND 0 0 0 ENDEAVOUR SILVER CORP COM 29258Y103 55 11100 SH DFND 0 0 0 ENDO INTL PLC SHS G30401106 130 17500 SH DFND 0 0 0 ENEL AMERICAS S A SPONSORED ADR 29274F104 13 80100 SH DFND 0 0 0 ENEL CHILE S.A. SPONSORED ADR 29278D105 5 59119 SH DFND 0 0 0 ENERGIZER HLDGS INC NEW COM 29272W109 228 4800 SH DFND 0 0 0 ENERPLUS CORP COM 292766102 113 22500 SH DFND 0 0 0 ENERSYS COM 29275Y102 300 3300 SH DFND 0 0 0 ENLINK MIDSTREAM LLC COM UNIT REP LTD 29336T100 98 22800 SH DFND 0 0 0 ENPHASE ENERGY INC COM 29355A107 75921 468182 SH DFND 0 0 0 ENPHASE ENERGY INC COM 29355A107 1232 7600 SH DFND 1 0 0 ENSIGN GROUP INC COM 29358P101 338 3600 SH DFND 0 0 0 ENSTAR GROUP LIMITED SHS G3075P101 222 900 SH DFND 0 0 0 ENTEGRIS INC COM 29362U104 1152 10300 SH DFND 0 0 0 ENTERGY CORP NEW COM 29364G103 316901 3185894 SH DFND 0 0 0 ENTERGY CORP NEW COM 29364G103 1263 12700 SH DFND 1 0 0 ENVESTNET INC COM 29404K106 311 4300 SH DFND 0 0 0 ENVISTA HOLDINGS CORPORATION COM 29415F104 510 12500 SH DFND 0 0 0 EOG RES INC COM 26875P101 15138 208714 SH DFND 0 0 0 EOG RES INC COM 26875P101 2832 39050 SH DFND 1 0 0 EPAM SYS INC COM 29414B104 6664 16800 SH DFND 0 0 0 EPAM SYS INC COM 29414B104 1468 3700 SH DFND 1 0 0 EPR PPTYS COM SH BEN INT 26884U109 293 6300 SH DFND 0 0 0 EPR PPTYS COM SH BEN INT 26884U109 508 10900 SH DFND 1 0 0 EQT CORP COM 26884L109 399 21500 SH DFND 0 0 0 EQUIFAX INC COM 294429105 117843 650602 SH DFND 0 0 0 EQUIFAX INC COM 294429105 1570 8667 SH DFND 1 0 0 EQUINIX INC COM 29444U700 609955 897533 SH DFND 0 0 0 EQUINIX INC COM 29444U700 20713 30479 SH DFND 1 0 0 EQUINOX GOLD CORP COM 29446Y502 146 18285 SH DFND 0 0 0 EQUITABLE HLDGS INC COM 29452E101 4763 146027 SH DFND 0 0 0 EQUITABLE HLDGS INC COM 29452E101 748 22924 SH DFND 1 0 0 EQUITRANS MIDSTREAM CORP COM 294600101 275 33699 SH DFND 0 0 0 EQUITY COMWLTH COM SH BEN INT 294628102 253 9100 SH DFND 0 0 0 EQUITY COMWLTH COM SH BEN INT 294628102 464 16700 SH DFND 1 0 0 EQUITY LIFESTYLE PPTYS INC COM 29472R108 3099 48700 SH DFND 0 0 0 EQUITY LIFESTYLE PPTYS INC COM 29472R108 2317 36400 SH DFND 1 0 0 EQUITY RESIDENTIAL SH BEN INT 29476L107 19754 275785 SH DFND 0 0 0 EQUITY RESIDENTIAL SH BEN INT 29476L107 5584 77950 SH DFND 1 0 0 ERIE INDTY CO CL A 29530P102 1905 8623 SH DFND 0 0 0 ERIE INDTY CO CL A 29530P102 398 1800 SH DFND 1 0 0 ESCO TECHNOLOGIES INC COM 296315104 229 2100 SH DFND 0 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 3629 129389 SH DFND 0 0 0 ESSENT GROUP LTD COM G3198U102 40126 844938 SH DFND 0 0 0 ESSENTIAL PPTYS RLTY TR INC COM 29670E107 183 8000 SH DFND 0 0 0 ESSENTIAL PPTYS RLTY TR INC COM 29670E107 334 14640 SH DFND 1 0 0 ESSENTIAL UTILS INC COM 29670G102 200532 4481150 SH DFND 0 0 0 ESSENTIAL UTILS INC COM 29670G102 2728 60969 SH DFND 1 0 0 ESSEX PPTY TR INC COM 297178105 9250 34028 SH DFND 0 0 0 ESSEX PPTY TR INC COM 297178105 3684 13550 SH DFND 1 0 0 ETSY INC COM 29786A106 67355 333984 SH DFND 0 0 0 ETSY INC COM 29786A106 1613 8000 SH DFND 1 0 0 EURONAV NV SHS B38564108 138 15076 SH DFND 0 0 0 EURONET WORLDWIDE INC COM 298736109 581 4200 SH DFND 0 0 0 EVERBRIDGE INC COM 29978A104 55764 460175 SH DFND 0 0 0 EVERBRIDGE INC COM 29978A104 149 1228 SH DFND 1 0 0 EVERCORE INC CLASS A 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GROUP LTD SHS M53213100 1048 178669 SH DFND 0 0 0 ICL GROUP LTD SHS M53213100 46 7794 SH DFND 1 0 0 ICU MED INC COM 44930G107 288 1400 SH DFND 0 0 0 IDACORP INC COM 451107106 420 4200 SH DFND 0 0 0 IDEX CORP COM 45167R104 329838 1575763 SH DFND 0 0 0 IDEX CORP COM 45167R104 5758 27507 SH DFND 1 0 0 IDEXX LABS INC COM 45168D104 106389 217428 SH DFND 0 0 0 IDEXX LABS INC COM 45168D104 2809 5740 SH DFND 1 0 0 IGM BIOSCIENCES INC COM 449585108 20309 264812 SH DFND 0 0 0 IGM BIOSCIENCES INC COM 449585108 8010 104451 SH DFND 1 0 0 IHS MARKIT LTD SHS G47567105 14985 154832 SH DFND 0 0 0 IHS MARKIT LTD SHS G47567105 2504 25877 SH DFND 1 0 0 II-VI INC COM 902104108 275138 4024263 SH DFND 0 0 0 II-VI INC COM 902104108 7299 106752 SH DFND 1 0 0 ILLINOIS TOOL WKS INC COM 452308109 54117 244299 SH DFND 0 0 0 ILLINOIS TOOL WKS INC COM 452308109 4984 22500 SH DFND 1 0 0 ILLUMINA INC COM 452327109 84226 219304 SH DFND 0 0 0 ILLUMINA INC COM 452327109 25510 66421 SH DFND 1 0 0 IMMUNITYBIO INC COM 45256X103 1144 48195 SH DFND 0 0 0 IMMUNOGEN INC COM 45253H101 130 16100 SH DFND 0 0 0 IMPERIAL OIL LTD COM NEW 453038408 1790 73914 SH DFND 0 0 0 IMPERIAL OIL LTD COM NEW 453038408 482 19881 SH DFND 1 0 0 INCYTE CORP COM 45337C102 88004 1082856 SH DFND 0 0 0 INCYTE CORP COM 45337C102 21571 265428 SH DFND 1 0 0 INDEPENDENCE RLTY TR INC COM 45378A106 113 7400 SH DFND 0 0 0 INDEPENDENCE RLTY TR INC COM 45378A106 231 15200 SH DFND 1 0 0 INDEPENDENT BANK CORP MASS COM 453836108 210 2500 SH DFND 0 0 0 INDEPENDENT BK GROUP INC COM 45384B106 202 2800 SH DFND 0 0 0 INDUSTRIAL LOGISTICS PPTYS T COM SHS BEN INT 456237106 127 5500 SH DFND 0 0 0 INDUSTRIAL LOGISTICS PPTYS T COM SHS BEN INT 456237106 205 8851 SH DFND 1 0 0 INFINERA CORP COM 45667G103 135 14000 SH DFND 0 0 0 INGERSOLL RAND INC COM 45687V106 7283 147995 SH DFND 0 0 0 INGERSOLL RAND INC COM 45687V106 1246 25317 SH DFND 1 0 0 INGEVITY CORP COM 45688C107 31142 412316 SH DFND 0 0 0 INGEVITY CORP COM 45688C107 2559 33874 SH DFND 1 0 0 INGREDION INC COM 457187102 450 5000 SH DFND 0 0 0 INNOVATIVE INDL PPTYS INC COM 45781V101 288 1600 SH DFND 0 0 0 INNOVATIVE INDL PPTYS INC COM 45781V101 610 3384 SH DFND 1 0 0 INOVIO PHARMACEUTICALS INC COM NEW 45773H201 2093 225579 SH DFND 0 0 0 INPHI CORP COM 45772F107 749 4200 SH DFND 0 0 0 INSIGHT ENTERPRISES INC COM 45765U103 277 2900 SH DFND 0 0 0 INSMED INC COM PAR $.01 457669307 12936 379803 SH DFND 0 0 0 INSMED INC COM PAR $.01 457669307 4832 141879 SH DFND 1 0 0 INSPERITY INC COM 45778Q107 251 3000 SH DFND 0 0 0 INSPIRE MED SYS INC COM 457730109 414 2000 SH DFND 0 0 0 INSULET CORP COM 45784P101 5244 20100 SH DFND 0 0 0 INSULET CORP COM 45784P101 1122 4300 SH DFND 1 0 0 INTEGER HLDGS CORP COM 45826H109 203 2200 SH DFND 0 0 0 INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 387 5600 SH DFND 0 0 0 INTEL CORP COM 458140100 609856 9529004 SH DFND 0 0 0 INTEL CORP COM 458140100 27710 432968 SH DFND 1 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 40699 507112 SH DFND 0 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 12495 155695 SH DFND 1 0 0 INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 394 5400 SH DFND 0 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 2358 102176 SH DFND 0 0 0 INTERCONTINENTAL EXCHANGE IN COM 45866F104 43393 388553 SH DFND 0 0 0 INTERCONTINENTAL EXCHANGE IN COM 45866F104 4772 42727 SH DFND 1 0 0 INTERCORP FINL SVCS INC SHS P5626F128 344 11500 SH DFND 0 0 0 INTERNATIONAL BUSINESS MACHS COM 459200101 51906 389510 SH DFND 0 0 0 INTERNATIONAL BUSINESS MACHS COM 459200101 20143 151157 SH DFND 1 0 0 INTERNATIONAL FLAVORS&FRAGRA COM 459506101 97003 694811 SH DFND 0 0 0 INTERNATIONAL FLAVORS&FRAGRA COM 459506101 17205 123239 SH DFND 1 0 0 INTERNATIONAL PAPER CO COM 460146103 70381 1301663 SH DFND 0 0 0 INTERNATIONAL PAPER CO COM 460146103 7373 136354 SH DFND 1 0 0 INTERPUBLIC GROUP COS INC COM 460690100 7792 266862 SH DFND 0 0 0 INTERPUBLIC GROUP COS INC COM 460690100 762 26100 SH DFND 1 0 0 INTRA CELLULAR THERAPIES INC COM 46116X101 3741 110267 SH DFND 0 0 0 INTUIT COM 461202103 241266 629841 SH DFND 0 0 0 INTUIT COM 461202103 15301 39943 SH DFND 1 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 350827 474771 SH DFND 0 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 5647 7642 SH DFND 1 0 0 INVESCO EXCHANGE TRADED FD T INVESCO MSCI 46137V407 2191 29005 SH DFND 0 0 0 INVESCO LTD SHS G491BT108 4592 182101 SH DFND 0 0 0 INVESCO LTD SHS G491BT108 642 25450 SH DFND 1 0 0 INVESCO MORTGAGE CAPITAL INC COM 46131B100 52 13035 SH DFND 0 0 0 INVESTORS BANCORP INC NEW COM 46146L101 251 17100 SH DFND 0 0 0 INVITAE CORP COM 46185L103 481 12600 SH DFND 0 0 0 INVITATION HOMES INC COM 46187W107 5268 164665 SH DFND 0 0 0 INVITATION HOMES INC COM 46187W107 3780 118161 SH DFND 1 0 0 IONIS PHARMACEUTICALS INC COM 462222100 1744 38800 SH DFND 0 0 0 IONIS PHARMACEUTICALS INC COM 462222100 459 10200 SH DFND 1 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 288 9100 SH DFND 0 0 0 IPG PHOTONICS CORP COM 44980X109 249674 1183623 SH DFND 0 0 0 IPG PHOTONICS CORP COM 44980X109 485 2300 SH DFND 1 0 0 IQIYI INC SPONSORED ADS 46267X108 5784 348000 SH DFND 0 0 0 IQVIA HLDGS INC COM 46266C105 14819 76723 SH DFND 0 0 0 IQVIA HLDGS INC COM 46266C105 2421 12537 SH DFND 1 0 0 IRHYTHM TECHNOLOGIES INC COM 450056106 278 2000 SH DFND 0 0 0 IRIDIUM COMMUNICATIONS INC COM 46269C102 351 8500 SH DFND 0 0 0 IROBOT CORP COM 462726100 135285 1107261 SH DFND 0 0 0 IRON MTN INC NEW COM 46284V101 4309 116425 SH DFND 0 0 0 IRON MTN INC NEW COM 46284V101 715 19321 SH DFND 1 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 12912 1154927 SH DFND 0 0 0 ISHARES GOLD TR ISHARES 464285105 448 27578 SH DFND 0 0 0 ISHARES INC MSCI FRONTIER 464286145 3682 124870 SH DFND 1 0 0 ISHARES INC MSCI GBL ETF NEW 46434G848 914 21705 SH DFND 0 0 0 ISHARES INC MSCI PAC JP ETF 464286665 269 5356 SH DFND 0 0 0 ISHARES INC MSCI JPN ETF NEW 46434G822 2719 39677 SH DFND 0 0 0 ISHARES INC MSCI CDA ETF 464286509 1226 36000 SH DFND 0 0 0 ISHARES TR USD INV GRDE ETF 464288620 3392 57450 SH DFND 0 0 0 ISHARES TR USD INV GRDE ETF 464288620 4306 72928 SH DFND 1 0 0 ISHARES TR CORE US AGGBD ET 464287226 54393 477843 SH DFND 0 0 0 ISHARES TR CORE US AGGBD ET 464287226 20010 175790 SH DFND 1 0 0 ISHARES TR ISHS 5-10YR INVT 464288638 1114 18800 SH DFND 0 0 0 ISHARES TR ISHS 5-10YR INVT 464288638 145 2450 SH DFND 1 0 0 ISHARES TR TIPS BD ETF 464287176 186088 1482770 SH DFND 0 0 0 ISHARES TR TIPS BD ETF 464287176 17936 142920 SH DFND 1 0 0 ISHARES TR IBOXX INV CP ETF 464287242 25019 192430 SH DFND 0 0 0 ISHARES TR IBOXX INV CP ETF 464287242 5257 40430 SH DFND 1 0 0 ISHARES TR US HOME CONS ETF 464288752 11008 162200 SH Put DFND 0 0 0 ISHARES TR US HOME CONS ETF 464288752 14930 220000 SH Put DFND 1 0 0 ISHARES TR MSCI INDIA ETF 46429B598 1134 26900 SH DFND 1 0 0 ISHARES TR JPMORGAN USD EMG 464288281 9364 86000 SH DFND 1 0 0 ISHARES TR 3 7 YR TREAS BD 464288661 19008 146340 SH DFND 0 0 0 ISHARES TR PHLX SEMICND ETF 464287523 2060 4858 SH DFND 0 0 0 ISHARES TR INTL DEV RE ETF 464288489 4366 157600 SH DFND 0 0 0 ISHARES TR GLOB INDSTRL ETF 464288729 1368 11800 SH DFND 0 0 0 ISHARES TR GLOBAL FINLS ETF 464287333 2720 37065 SH DFND 0 0 0 ISHARES TR GLOBAL ENERG ETF 464287341 978 39662 SH DFND 0 0 0 ISHARES TR U.S. CNSM SV ETF 464287580 1888 25230 SH DFND 0 0 0 ISHARES TR GL CLEAN ENE ETF 464288224 1166 48000 SH DFND 0 0 0 ISHARES TR HDG MSCI JAPAN 46434V886 7426 190755 SH DFND 0 0 0 ISHARES TR CUR HED MSCI GER 46434V704 5651 176515 SH DFND 0 0 0 ISHARES TR CUR HD EURZN ETF 46434V639 6532 190770 SH DFND 0 0 0 ISHARES TR RUS 1000 VAL ETF 464287598 3787 24990 SH DFND 0 0 0 ISHARES TR ESG AWR US AGRGT 46435U549 35896 656000 SH DFND 0 0 0 ISHARES TR US HOME CONS ETF 464288752 941 13865 SH DFND 0 0 0 ITRON INC COM 465741106 239 2700 SH DFND 0 0 0 ITT INC COM 45073V108 618 6800 SH DFND 0 0 0 J & J SNACK FOODS CORP COM 466032109 204 1300 SH DFND 0 0 0 J2 GLOBAL INC COM 48123V102 384 3200 SH DFND 0 0 0 JABIL INC COM 466313103 527 10100 SH DFND 0 0 0 JACOBS ENGR GROUP INC COM 469814107 5968 46164 SH DFND 0 0 0 JACOBS ENGR GROUP INC COM 469814107 1398 10816 SH DFND 1 0 0 JANUS HENDERSON GROUP PLC ORD SHS G4474Y214 371 11900 SH DFND 0 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 37300 226926 SH DFND 0 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 764 4651 SH DFND 1 0 0 JBG SMITH PPTYS COM 46590V100 321 10100 SH DFND 0 0 0 JBG SMITH PPTYS COM 46590V100 563 17700 SH DFND 1 0 0 JD.COM INC SPON ADR CL A 47215P106 63100 1523492 SH DFND 0 0 0 JD.COM INC SPON ADR CL A 47215P106 13963 337131 SH DFND 1 0 0 JEFFERIES FINL GROUP INC COM 47233W109 485 16100 SH DFND 0 0 0 JINKOSOLAR HLDG CO LTD SPONSORED ADR 47759T100 746 17900 SH DFND 0 0 0 JOHN BEAN TECHNOLOGIES CORP COM 477839104 333 2500 SH DFND 0 0 0 JOHNSON & JOHNSON COM 478160104 181763 1105951 SH DFND 0 0 0 JOHNSON & JOHNSON COM 478160104 43250 263157 SH DFND 1 0 0 JOHNSON CTLS INTL PLC SHS G51502105 633216 10611958 SH DFND 0 0 0 JOHNSON CTLS INTL PLC SHS G51502105 4861 81473 SH DFND 1 0 0 JONES LANG LASALLE INC COM 48020Q107 698 3900 SH DFND 0 0 0 JOYY INC ADS REPSTG COM A 46591M109 8673 92537 SH DFND 0 0 0 JPMORGAN CHASE & CO COM 46625H100 222809 1463632 SH DFND 0 0 0 JPMORGAN CHASE & CO COM 46625H100 50727 333227 SH DFND 1 0 0 JUNIPER NETWORKS INC COM 48203R104 11183 441478 SH DFND 0 0 0 JUNIPER NETWORKS INC COM 48203R104 1968 77693 SH DFND 1 0 0 KADANT INC COM 48282T104 13004 70288 SH DFND 0 0 0 KADANT INC COM 48282T104 1097 5927 SH DFND 1 0 0 KADMON HLDGS INC COM 48283N106 55 14200 SH DFND 0 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 9543 371445 SH DFND 0 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 4991 194284 SH DFND 1 0 0 KANSAS CITY SOUTHERN COM NEW 485170302 10566 40034 SH DFND 0 0 0 KANSAS CITY SOUTHERN COM NEW 485170302 1781 6750 SH DFND 1 0 0 KAR AUCTION SVCS INC COM 48238T109 155 10300 SH DFND 0 0 0 KARUNA THERAPEUTICS INC COM 48576A100 42700 355158 SH DFND 0 0 0 KARUNA THERAPEUTICS INC COM 48576A100 18337 152513 SH DFND 1 0 0 KB HOME COM 48666K109 321 6900 SH DFND 0 0 0 KBR INC COM 48242W106 457 11900 SH DFND 0 0 0 KE HLDGS INC SPONSORED ADS 482497104 75460 1324320 SH DFND 0 0 0 KE HLDGS INC SPONSORED ADS 482497104 16865 295978 SH DFND 1 0 0 KELLOGG CO COM 487836108 6726 106258 SH DFND 0 0 0 KELLOGG CO COM 487836108 1067 16850 SH DFND 1 0 0 KEMPER CORP COM 488401100 383 4800 SH DFND 0 0 0 KENNAMETAL INC COM 489170100 240 6000 SH DFND 0 0 0 KENNEDY-WILSON HOLDINGS INC COM 489398107 192 9500 SH DFND 0 0 0 KENNEDY-WILSON HOLDINGS INC COM 489398107 342 16900 SH DFND 1 0 0 KEURIG DR PEPPER INC COM 49271V100 7761 225800 SH DFND 0 0 0 KEURIG DR PEPPER INC COM 49271V100 1313 38200 SH DFND 1 0 0 KEYCORP COM 493267108 9001 450494 SH DFND 0 0 0 KEYCORP COM 493267108 1289 64500 SH DFND 1 0 0 KEYSIGHT TECHNOLOGIES INC COM 49338L103 11286 78700 SH DFND 0 0 0 KEYSIGHT TECHNOLOGIES INC COM 49338L103 1749 12200 SH DFND 1 0 0 KILROY RLTY CORP COM 49427F108 532 8100 SH DFND 0 0 0 KILROY RLTY CORP COM 49427F108 1096 16700 SH DFND 1 0 0 KIMBERLY-CLARK CORP COM 494368103 63794 458784 SH DFND 0 0 0 KIMBERLY-CLARK CORP COM 494368103 7039 50623 SH DFND 1 0 0 KIMCO RLTY CORP COM 49446R109 1204 64209 SH DFND 0 0 0 KIMCO RLTY CORP COM 49446R109 1106 59000 SH DFND 1 0 0 KINDER MORGAN INC DEL COM 49456B101 12597 756569 SH DFND 0 0 0 KINDER MORGAN INC DEL COM 49456B101 5132 308206 SH DFND 1 0 0 KINGSOFT CLOUD HLDGS LTD ADS 49639K101 2544 64700 SH DFND 0 0 0 KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 33247 1796137 SH DFND 0 0 0 KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 12792 691096 SH DFND 1 0 0 KINROSS GOLD CORP COM 496902404 2654 398622 SH DFND 0 0 0 KINROSS GOLD CORP COM 496902404 505 75804 SH DFND 1 0 0 KINSALE CAP GROUP INC COM 49714P108 279 1693 SH DFND 0 0 0 KIRKLAND LAKE GOLD LTD COM 49741E100 3841 113748 SH DFND 0 0 0 KIRKLAND LAKE GOLD LTD COM 49741E100 1929 57141 SH DFND 1 0 0 KITE RLTY GROUP TR COM NEW 49803T300 137 7100 SH DFND 0 0 0 KITE RLTY GROUP TR COM NEW 49803T300 237 12300 SH DFND 1 0 0 KKR & CO INC COM 48251W104 8085 165498 SH DFND 0 0 0 KKR & CO INC COM 48251W104 1624 33248 SH DFND 1 0 0 KLA CORP COM NEW 482480100 797652 2414201 SH DFND 0 0 0 KLA CORP COM NEW 482480100 26481 80148 SH DFND 1 0 0 KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 1612 33530 SH DFND 0 0 0 KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 3580 74439 SH DFND 1 0 0 KODIAK SCIENCES INC COM 50015M109 295 2600 SH DFND 0 0 0 KOHLS CORP COM 500255104 715 12000 SH DFND 0 0 0 KORN FERRY COM NEW 500643200 287 4600 SH DFND 0 0 0 KORNIT DIGITAL LTD SHS M6372Q113 307 3100 SH DFND 0 0 0 KOSMOS ENERGY LTD COM 500688106 131 42600 SH DFND 0 0 0 KRAFT HEINZ CO COM 500754106 9666 241639 SH DFND 0 0 0 KRAFT HEINZ CO COM 500754106 1794 44850 SH DFND 1 0 0 KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 232 8500 SH DFND 0 0 0 KROGER CO COM 501044101 10590 294246 SH DFND 0 0 0 KROGER CO COM 501044101 2020 56118 SH DFND 1 0 0 KRONOS BIO INC COM 50107A104 1771 60499 SH DFND 0 0 0 KRONOS BIO INC COM 50107A104 1233 42130 SH DFND 1 0 0 KRYSTAL BIOTECH INC COM 501147102 23188 300993 SH DFND 0 0 0 KRYSTAL BIOTECH INC COM 501147102 8928 115887 SH DFND 1 0 0 KULICKE & SOFFA INDS INC COM 501242101 211 4300 SH DFND 0 0 0 L BRANDS INC COM 501797104 2295 37105 SH DFND 0 0 0 L3HARRIS TECHNOLOGIES INC COM 502431109 15498 76462 SH DFND 0 0 0 L3HARRIS TECHNOLOGIES INC COM 502431109 3209 15834 SH DFND 1 0 0 LABORATORY CORP AMER HLDGS COM NEW 50540R409 16625 65189 SH DFND 0 0 0 LABORATORY CORP AMER HLDGS COM NEW 50540R409 1607 6300 SH DFND 1 0 0 LADDER CAP CORP CL A 505743104 119 10100 SH DFND 0 0 0 LAM RESEARCH CORP COM 512807108 794740 1335159 SH DFND 0 0 0 LAM RESEARCH CORP COM 512807108 14504 24367 SH DFND 1 0 0 LAMAR ADVERTISING CO NEW CL A 512816109 629 6700 SH DFND 0 0 0 LAMB WESTON HLDGS INC COM 513272104 3796 49000 SH DFND 0 0 0 LAMB WESTON HLDGS INC COM 513272104 744 9600 SH DFND 1 0 0 LANCASTER COLONY CORP COM 513847103 298 1700 SH DFND 0 0 0 LANDSTAR SYS INC COM 515098101 462 2800 SH DFND 0 0 0 LAS VEGAS SANDS CORP COM 517834107 7369 121286 SH DFND 0 0 0 LAS VEGAS SANDS CORP COM 517834107 1428 23500 SH DFND 1 0 0 LATTICE SEMICONDUCTOR CORP COM 518415104 441 9800 SH DFND 0 0 0 LAUDER ESTEE COS INC CL A 518439104 123042 423042 SH DFND 0 0 0 LAUDER ESTEE COS INC CL A 518439104 21057 72400 SH DFND 1 0 0 LCI INDS COM 50189K103 265 2000 SH DFND 0 0 0 LEAR CORP COM NEW 521865204 3108 17148 SH DFND 0 0 0 LEAR CORP COM NEW 521865204 734 4050 SH DFND 1 0 0 LEGGETT & PLATT INC COM 524660107 1035 22679 SH DFND 0 0 0 LEIDOS HOLDINGS INC COM 525327102 4573 47500 SH DFND 0 0 0 LEIDOS HOLDINGS INC COM 525327102 809 8400 SH DFND 1 0 0 LEMONADE INC COM 52567D107 234 2512 SH DFND 0 0 0 LENDINGTREE INC NEW COM 52603B107 213 1000 SH DFND 0 0 0 LENNAR CORP CL A 526057104 37955 374937 SH DFND 0 0 0 LENNAR CORP CL A 526057104 4650 45940 SH DFND 1 0 0 LENNOX INTL INC COM 526107107 4547 14593 SH DFND 0 0 0 LENNOX INTL INC COM 526107107 1195 3836 SH DFND 1 0 0 LESLIES INC COM 527064109 89188 3641775 SH DFND 0 0 0 LESLIES INC COM 527064109 980 40036 SH DFND 1 0 0 LEXINFINTECH HLDGS LTD ADR 528877103 429 42600 SH DFND 0 0 0 LEXINGTON REALTY TRUST COM 529043101 255 23000 SH DFND 0 0 0 LEXINGTON REALTY TRUST COM 529043101 420 37800 SH DFND 1 0 0 LGI HOMES INC COM 50187T106 269 1800 SH DFND 0 0 0 LHC GROUP INC COM 50187A107 23197 121319 SH DFND 0 0 0 LI AUTO INC SPONSORED ADS 50202M102 4687 187466 SH DFND 0 0 0 LIBERTY BROADBAND CORP COM SER A 530307107 900 6200 SH DFND 0 0 0 LIBERTY BROADBAND CORP COM SER A 530307107 247 1700 SH DFND 1 0 0 LIBERTY BROADBAND CORP COM SER C 530307305 8107 53995 SH DFND 0 0 0 LIBERTY BROADBAND CORP COM SER C 530307305 1604 10681 SH DFND 1 0 0 LIBERTY GLOBAL PLC SHS CL A G5480U104 1459 56869 SH DFND 0 0 0 LIBERTY GLOBAL PLC SHS CL A G5480U104 431 16778 SH DFND 1 0 0 LIBERTY GLOBAL PLC SHS CL C G5480U120 3331 130410 SH DFND 0 0 0 LIBERTY GLOBAL PLC SHS CL C G5480U120 632 24741 SH DFND 1 0 0 LIBERTY LATIN AMERICA LTD COM CL C G9001E128 140 10760 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 2577 59525 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 615 14209 SH DFND 1 0 0 LIBERTY MEDIA CORP DEL COM A SIRIUSXM 531229409 1079 24491 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM A SIRIUSXM 531229409 320 7250 SH DFND 1 0 0 LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 2385 54080 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 796 18045 SH DFND 1 0 0 LIFE STORAGE INC COM 53223X107 460 5350 SH DFND 0 0 0 LIFE STORAGE INC COM 53223X107 907 10550 SH DFND 1 0 0 LIGAND PHARMACEUTICALS INC COM NEW 53220K504 213 1400 SH DFND 0 0 0 LIGHTSPEED POS INC SUB VTG SHS 53227R106 321 5100 SH DFND 0 0 0 LILLY ELI & CO COM 532457108 131109 701793 SH DFND 0 0 0 LILLY ELI & CO COM 532457108 10565 56550 SH DFND 1 0 0 LINCOLN ELEC HLDGS INC COM 533900106 492 4000 SH DFND 0 0 0 LINCOLN NATL CORP IND COM 534187109 5286 84884 SH DFND 0 0 0 LINCOLN NATL CORP IND COM 534187109 928 14911 SH DFND 1 0 0 LINDE PLC SHS G5494J103 85785 305522 SH DFND 0 0 0 LINDE PLC SHS G5494J103 68992 245714 SH DFND 1 0 0 LIONS GATE ENTMNT CORP CL B NON VTG 535919500 142 11000 SH DFND 0 0 0 LITHIA MTRS INC CL A 536797103 780 2000 SH DFND 0 0 0 LITTELFUSE INC COM 537008104 502 1900 SH DFND 0 0 0 LIVANOVA PLC SHS G5509L101 273 3700 SH DFND 0 0 0 LIVE NATION ENTERTAINMENT IN COM 538034109 4940 58359 SH DFND 0 0 0 LIVE NATION ENTERTAINMENT IN COM 538034109 3098 36600 SH DFND 1 0 0 LIVENT CORP COM 53814L108 220 12700 SH DFND 0 0 0 LIVEPERSON INC COM 538146101 253 4800 SH DFND 0 0 0 LIVERAMP HLDGS INC COM 53815P108 265 5100 SH DFND 0 0 0 LKQ CORP COM 501889208 5110 120716 SH DFND 0 0 0 LKQ CORP COM 501889208 808 19100 SH DFND 1 0 0 LOCKHEED MARTIN CORP COM 539830109 21390 57889 SH DFND 0 0 0 LOCKHEED MARTIN CORP COM 539830109 2763 7478 SH DFND 1 0 0 LOEWS CORP COM 540424108 5752 112177 SH DFND 0 0 0 LOEWS CORP COM 540424108 830 16181 SH DFND 1 0 0 LOGITECH INTL S A SHS H50430232 291707 2769200 SH DFND 0 0 0 LOGITECH INTL S A SHS H50430232 20445 194088 SH DFND 1 0 0 LOMA NEGRA CORP SPONSORED ADS 54150E104 66 32364 SH DFND 0 0 0 LOUISIANA PAC CORP COM 546347105 56598 1020515 SH DFND 0 0 0 LOUISIANA PAC CORP COM 546347105 6235 112424 SH DFND 1 0 0 LOWES COS INC COM 548661107 194132 1020780 SH DFND 0 0 0 LOWES COS INC COM 548661107 9756 51300 SH DFND 1 0 0 LPL FINL HLDGS INC COM 50212V100 881 6200 SH DFND 0 0 0 LTC PPTYS INC COM 502175102 125 3000 SH DFND 0 0 0 LTC PPTYS INC COM 502175102 221 5300 SH DFND 1 0 0 LUCIRA HEALTH INC COM 54948U105 865 71474 SH DFND 0 0 0 LUCIRA HEALTH INC COM 54948U105 613 50638 SH DFND 1 0 0 LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 3011 207391 SH DFND 0 0 0 LULULEMON ATHLETICA INC COM 550021109 84675 276074 SH DFND 0 0 0 LULULEMON ATHLETICA INC COM 550021109 2722 8875 SH DFND 1 0 0 LUMEN TECHNOLOGIES INC COM 550241103 5483 410690 SH DFND 0 0 0 LUMEN TECHNOLOGIES INC COM 550241103 1065 79772 SH DFND 1 0 0 LUMENTUM HLDGS INC COM 55024U109 539 5900 SH DFND 0 0 0 LUMINEX CORP DEL COM 55027E102 1729 54216 SH DFND 0 0 0 LYFT INC CL A COM 55087P104 65565 1037741 SH DFND 0 0 0 LYFT INC CL A COM 55087P104 4633 73331 SH DFND 1 0 0 LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 10023 96331 SH DFND 0 0 0 LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 1785 17150 SH DFND 1 0 0 M & T BK CORP COM 55261F104 9007 59409 SH DFND 0 0 0 M & T BK CORP COM 55261F104 1385 9135 SH DFND 1 0 0 M D C HLDGS INC COM 552676108 314 5292 SH DFND 0 0 0 MACERICH CO COM 554382101 109 9286 SH DFND 0 0 0 MACERICH CO COM 554382101 237 20304 SH DFND 1 0 0 MACK CALI RLTY CORP COM 554489104 105 6800 SH DFND 0 0 0 MACK CALI RLTY CORP COM 554489104 195 12600 SH DFND 1 0 0 MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 209 3600 SH DFND 0 0 0 MACYS INC COM 55616P104 368 22700 SH DFND 0 0 0 MADDEN STEVEN LTD COM 556269108 224 6000 SH DFND 0 0 0 MADISON SQUARE GRDN SPRT COR CL A 55825T103 210 1170 SH DFND 0 0 0 MAGNA INTL INC COM 559222401 8872 100747 SH DFND 0 0 0 MAGNA INTL INC COM 559222401 3381 38391 SH DFND 1 0 0 MAGNITE INC COM 55955D100 345 8300 SH DFND 0 0 0 MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 13502 427542 SH DFND 0 0 0 MANHATTAN ASSOCIATES INC COM 562750109 528 4500 SH DFND 0 0 0 MANPOWERGROUP INC COM 56418H100 435 4400 SH DFND 0 0 0 MANULIFE FINL CORP COM 56501R106 23362 1086265 SH DFND 0 0 0 MANULIFE FINL CORP COM 56501R106 2886 134202 SH DFND 1 0 0 MARATHON OIL CORP COM 565849106 1391 130211 SH DFND 0 0 0 MARATHON PETE CORP COM 56585A102 14485 270802 SH DFND 0 0 0 MARATHON PETE CORP COM 56585A102 2311 43207 SH DFND 1 0 0 MARKEL CORP COM 570535104 5100 4475 SH DFND 0 0 0 MARKEL CORP COM 570535104 1060 930 SH DFND 1 0 0 MARKETAXESS HLDGS INC COM 57060D108 8982 18040 SH DFND 0 0 0 MARKETAXESS HLDGS INC COM 57060D108 1215 2440 SH DFND 1 0 0 MARRIOTT INTL INC NEW CL A 571903202 140239 946855 SH DFND 0 0 0 MARRIOTT INTL INC NEW CL A 571903202 2770 18702 SH DFND 1 0 0 MARRIOTT VACTINS WORLDWID CO COM 57164Y107 557 3200 SH DFND 0 0 0 MARSH & MCLENNAN COS INC COM 571748102 34043 279502 SH DFND 0 0 0 MARSH & MCLENNAN COS INC COM 571748102 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831865209 351530 5199373 SH DFND 0 0 0 SMITH A O CORP COM 831865209 5792 85674 SH DFND 1 0 0 SMUCKER J M CO COM NEW 832696405 12885 101834 SH DFND 0 0 0 SMUCKER J M CO COM NEW 832696405 1478 11684 SH DFND 1 0 0 SNAP INC CL A 83304A106 13919 266200 SH DFND 0 0 0 SNAP INC CL A 83304A106 9843 188233 SH DFND 1 0 0 SNAP ON INC COM 833034101 10992 47636 SH DFND 0 0 0 SNAP ON INC COM 833034101 1110 4811 SH DFND 1 0 0 SNOWFLAKE INC CL A 833445109 30203 131732 SH DFND 0 0 0 SNOWFLAKE INC CL A 833445109 324 1412 SH DFND 1 0 0 SO YOUNG INTERNATIONAL INC SPONSORED ADS 83356Q108 116 11800 SH DFND 0 0 0 SOLAREDGE TECHNOLOGIES INC COM 83417M104 192669 670291 SH DFND 0 0 0 SOLAREDGE TECHNOLOGIES INC COM 83417M104 2511 8737 SH DFND 1 0 0 SONOCO PRODS CO COM 835495102 21450 338851 SH DFND 0 0 0 SONOCO PRODS CO COM 835495102 1941 30668 SH DFND 1 0 0 SONOS INC COM 83570H108 221 5900 SH DFND 0 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 182 22000 SH DFND 0 0 0 SOUTH ST CORP COM 840441109 416 5300 SH DFND 0 0 0 SOUTHERN CO COM 842587107 322158 5182723 SH DFND 0 0 0 SOUTHERN CO COM 842587107 4261 68550 SH DFND 1 0 0 SOUTHERN COPPER CORP COM 84265V105 5421 79871 SH DFND 0 0 0 SOUTHWEST AIRLS CO COM 844741108 9894 162038 SH DFND 0 0 0 SOUTHWEST AIRLS CO COM 844741108 915 14980 SH DFND 1 0 0 SOUTHWEST GAS HLDGS INC COM 844895102 309 4500 SH DFND 0 0 0 SOUTHWESTERN ENERGY CO COM 845467109 229 49200 SH DFND 0 0 0 SPDR INDEX SHS FDS DJ GLB RL ES ETF 78463X749 841 17800 SH DFND 0 0 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 1102 2780 SH DFND 0 0 0 SPDR SER TR DJ REIT ETF 78464A607 227 2400 SH DFND 0 0 0 SPDR SER TR BLMBRG BRC CNVRT 78464A359 1867 22400 SH DFND 0 0 0 SPDR SER TR S&P REGL BKG 78464A698 966 14565 SH DFND 0 0 0 SPDR SER TR SPDR BLOOMBERG 78468R663 7552 82540 SH DFND 0 0 0 SPDR SER TR BLOMBERG BRC INV 78468R200 9013 294160 SH DFND 0 0 0 SPECTRUM BRANDS HLDGS INC NE COM 84790A105 213 2500 SH DFND 0 0 0 SPECTRUM PHARMACEUTICALS INC COM 84763A108 60 18300 SH DFND 0 0 0 SPIRE INC COM 84857L101 318 4300 SH DFND 0 0 0 SPIRIT AEROSYSTEMS HLDGS INC COM CL A 848574109 399 8200 SH DFND 0 0 0 SPIRIT RLTY CAP INC NEW COM NEW 84860W300 357 8400 SH DFND 0 0 0 SPIRIT RLTY CAP INC NEW COM NEW 84860W300 682 16043 SH DFND 1 0 0 SPLUNK INC COM 848637104 496350 3663645 SH DFND 0 0 0 SPLUNK INC COM 848637104 1624 11985 SH DFND 1 0 0 SPOTIFY TECHNOLOGY S A SHS L8681T102 19007 70935 SH DFND 0 0 0 SPOTIFY TECHNOLOGY S A SHS L8681T102 13 47 SH DFND 1 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 39682 539372 SH DFND 0 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 15145 205863 SH DFND 1 0 0 SPROUTS FMRS MKT INC COM 85208M102 248 9300 SH DFND 0 0 0 SPS COMM INC COM 78463M107 248 2500 SH DFND 0 0 0 SPX FLOW INC COM 78469X107 203 3200 SH DFND 0 0 0 SQUARE INC CL A 852234103 58045 255649 SH DFND 0 0 0 SQUARE INC CL A 852234103 14992 66031 SH DFND 1 0 0 SS&C TECHNOLOGIES HLDGS INC COM 78467J100 4581 65563 SH DFND 0 0 0 SS&C TECHNOLOGIES HLDGS INC COM 78467J100 1076 15400 SH DFND 1 0 0 SSR MNG INC COM 784730103 904 63229 SH DFND 0 0 0 SSR MNG INC COM 784730103 200 14000 SH DFND 1 0 0 STAAR SURGICAL CO COM PAR $0.01 852312305 242 2300 SH DFND 0 0 0 STAG INDL INC COM 85254J102 373 11100 SH DFND 0 0 0 STAG INDL INC COM 85254J102 760 22600 SH DFND 1 0 0 STAMPS COM INC COM NEW 852857200 259 1300 SH DFND 0 0 0 STANLEY BLACK & DECKER INC COM 854502101 358795 1796943 SH DFND 0 0 0 STANLEY BLACK & DECKER INC COM 854502101 14239 71311 SH DFND 1 0 0 STANTEC INC COM 85472N109 110448 2580206 SH DFND 0 0 0 STANTEC INC COM 85472N109 1403 32775 SH DFND 1 0 0 STARBUCKS CORP COM 855244109 190970 1747684 SH DFND 0 0 0 STARBUCKS CORP COM 855244109 16608 151992 SH DFND 1 0 0 STARWOOD PPTY TR INC COM 85571B105 559 22600 SH DFND 0 0 0 STATE STR CORP COM 857477103 15505 184559 SH DFND 0 0 0 STATE STR CORP COM 857477103 12368 147221 SH DFND 1 0 0 STEEL DYNAMICS INC COM 858119100 3453 68024 SH DFND 0 0 0 STEEL DYNAMICS INC COM 858119100 716 14100 SH DFND 1 0 0 STELLANTIS N.V SHS N82405106 18415 1038767 SH DFND 0 0 0 STELLANTIS N.V SHS N82405106 8673 489199 SH DFND 1 0 0 STEPAN CO COM 858586100 216 1700 SH DFND 0 0 0 STERICYCLE INC COM 858912108 466 6900 SH DFND 0 0 0 STERIS PLC SHS USD G8473T100 230679 1211045 SH DFND 0 0 0 STERIS PLC SHS USD G8473T100 1375 7216 SH DFND 1 0 0 STERLING BANCORP DEL COM 85917A100 299 13000 SH DFND 0 0 0 STIFEL FINL CORP COM 860630102 493 7700 SH DFND 0 0 0 STITCH FIX INC COM CL A 860897107 213 4300 SH DFND 0 0 0 STORE CAP CORP COM 862121100 660 19700 SH DFND 0 0 0 STORE CAP CORP COM 862121100 1152 34400 SH DFND 1 0 0 STRATEGIC ED INC COM 86272C103 26393 287163 SH DFND 0 0 0 STRIDE INC COM 86333M108 20235 672051 SH DFND 0 0 0 STRYKER CORPORATION COM 863667101 29899 122749 SH DFND 0 0 0 STRYKER CORPORATION COM 863667101 5481 22500 SH DFND 1 0 0 SUMMIT HOTEL PPTYS INC COM 866082100 73 7200 SH DFND 0 0 0 SUMMIT HOTEL PPTYS INC COM 866082100 161 15800 SH DFND 1 0 0 SUMMIT MATLS INC CL A 86614U100 244 8700 SH DFND 0 0 0 SUN CMNTYS INC COM 866674104 4936 32900 SH DFND 0 0 0 SUN CMNTYS INC COM 866674104 3301 22000 SH DFND 1 0 0 SUN LIFE FINANCIAL INC. COM 866796105 10449 206769 SH DFND 0 0 0 SUN LIFE FINANCIAL INC. COM 866796105 1979 39170 SH DFND 1 0 0 SUNCOR ENERGY INC NEW COM 867224107 9693 463713 SH DFND 0 0 0 SUNCOR ENERGY INC NEW COM 867224107 2092 100102 SH DFND 1 0 0 SUNNOVA ENERGY INTL INC. COM 86745K104 140234 3435416 SH DFND 0 0 0 SUNPOWER CORP COM 867652406 224 6700 SH DFND 0 0 0 SUNRUN INC COM 86771W105 148561 2456363 SH DFND 0 0 0 SUNRUN INC COM 86771W105 502 8296 SH DFND 1 0 0 SUNSTONE HOTEL INVS INC NEW COM 867892101 202 16200 SH DFND 0 0 0 SUNSTONE HOTEL INVS INC NEW COM 867892101 367 29500 SH DFND 1 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 7522 287336 SH DFND 0 0 0 SVB FINANCIAL GROUP COM 78486Q101 89010 180306 SH DFND 0 0 0 SVB FINANCIAL GROUP COM 78486Q101 1649 3340 SH DFND 1 0 0 SYNAPTICS INC COM 87157D109 325 2400 SH DFND 0 0 0 SYNCHRONY FINANCIAL COM 87165B103 8470 208328 SH DFND 0 0 0 SYNCHRONY FINANCIAL COM 87165B103 1432 35211 SH DFND 1 0 0 SYNEOS HEALTH INC CL A 87166B102 356 4700 SH DFND 0 0 0 SYNNEX CORP COM 87162W100 322 2800 SH DFND 0 0 0 SYNOPSYS INC COM 871607107 903320 3645654 SH DFND 0 0 0 SYNOPSYS INC COM 871607107 27850 112399 SH DFND 1 0 0 SYNOVUS FINL CORP COM NEW 87161C501 508 11100 SH DFND 0 0 0 SYSCO CORP COM 871829107 55477 704557 SH DFND 0 0 0 SYSCO CORP COM 871829107 2445 31050 SH DFND 1 0 0 TABULA RASA HEALTHCARE INC COM 873379101 14081 305766 SH DFND 0 0 0 TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 3083 149861 SH DFND 0 0 0 TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 333 16208 SH DFND 1 0 0 TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 7740 43800 SH DFND 0 0 0 TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 1325 7500 SH DFND 1 0 0 TAL EDUCATION GROUP SPONSORED ADS 874080104 122925 2282723 SH DFND 0 0 0 TAL EDUCATION GROUP SPONSORED ADS 874080104 226 4200 SH DFND 1 0 0 TALIS BIOMEDICAL CORP COM 87424L108 1545 120186 SH DFND 0 0 0 TALIS BIOMEDICAL CORP COM 87424L108 1094 85163 SH DFND 1 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 11432 129541 SH DFND 0 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 7809 88484 SH DFND 1 0 0 TANGER FACTORY OUTLET CTRS I COM 875465106 108 7100 SH DFND 0 0 0 TANGER FACTORY OUTLET CTRS I COM 875465106 195 12900 SH DFND 1 0 0 TAPESTRY INC COM 876030107 1580 38345 SH DFND 0 0 0 TARGA RES CORP COM 87612G101 530 16700 SH DFND 0 0 0 TARGET CORP COM 87612E106 55879 282116 SH DFND 0 0 0 TARGET CORP COM 87612E106 7604 38391 SH DFND 1 0 0 TAYLOR MORRISON HOME CORP COM 87724P106 311 10100 SH DFND 0 0 0 TC ENERGY CORP COM 87807B107 14566 317786 SH DFND 0 0 0 TC ENERGY CORP COM 87807B107 2915 63588 SH DFND 1 0 0 TCF FINL CORP COM 872307103 563 12119 SH DFND 0 0 0 TE CONNECTIVITY LTD REG SHS H84989104 15520 120208 SH DFND 0 0 0 TE CONNECTIVITY LTD REG SHS H84989104 2907 22513 SH DFND 1 0 0 TECHNIPFMC PLC COM G87110105 253 33000 SH DFND 0 0 0 TECK RESOURCES LTD CL B 878742204 2137 111594 SH DFND 0 0 0 TECK RESOURCES LTD CL B 878742204 607 31688 SH DFND 1 0 0 TEGNA INC COM 87901J105 307 16300 SH DFND 0 0 0 TELADOC HEALTH INC COM 87918A105 65633 361114 SH DFND 0 0 0 TELADOC HEALTH INC COM 87918A105 1759 9679 SH DFND 1 0 0 TELECOM ARGENTINA S A SPON ADR REP B 879273209 216 123067 SH DFND 0 0 0 TELEDYNE TECHNOLOGIES INC COM 879360105 6991 16900 SH DFND 0 0 0 TELEDYNE TECHNOLOGIES INC COM 879360105 1075 2600 SH DFND 1 0 0 TELEFLEX INCORPORATED COM 879369106 7168 17252 SH DFND 0 0 0 TELEFLEX INCORPORATED COM 879369106 1238 2980 SH DFND 1 0 0 TELUS CORPORATION COM 87971M103 4248 213304 SH DFND 0 0 0 TELUS CORPORATION COM 87971M103 426 21400 SH DFND 1 0 0 TEMPUR SEALY INTL INC COM 88023U101 508 13900 SH DFND 0 0 0 TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 55123 2690238 SH DFND 0 0 0 TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 5031 245538 SH DFND 1 0 0 TENET HEALTHCARE CORP COM NEW 88033G407 395 7600 SH DFND 0 0 0 TERADATA CORP DEL COM 88076W103 308 8000 SH DFND 0 0 0 TERADYNE INC COM 880770102 298087 2449763 SH DFND 0 0 0 TERADYNE INC COM 880770102 1375 11300 SH DFND 1 0 0 TEREX CORP NEW COM 880779103 230 5000 SH DFND 0 0 0 TERMINIX GLOBAL HOLDINGS INC COM 88087E100 37132 778933 SH DFND 0 0 0 TERMINIX GLOBAL HOLDINGS INC COM 88087E100 59 1245 SH DFND 1 0 0 TERNIUM SA SPONSORED ADS 880890108 13996 360347 SH DFND 0 0 0 TERRENO RLTY CORP COM 88146M101 324 5600 SH DFND 0 0 0 TERRENO RLTY CORP COM 88146M101 543 9400 SH DFND 1 0 0 TESLA INC COM 88160R101 331306 496020 SH DFND 0 0 0 TESLA INC COM 88160R101 35349 52923 SH DFND 1 0 0 TETRA TECH INC NEW COM 88162G103 341817 2518548 SH DFND 0 0 0 TETRA TECH INC NEW COM 88162G103 3949 29095 SH DFND 1 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 3175 278722 SH DFND 0 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 334 29328 SH DFND 1 0 0 TEXAS CAP BANCSHARES INC COM 88224Q107 305 4300 SH DFND 0 0 0 TEXAS INSTRS INC COM 882508104 122267 646950 SH DFND 0 0 0 TEXAS INSTRS INC COM 882508104 14533 76900 SH DFND 1 0 0 TEXAS PACIFIC LAND CORPORATI COM 88262P102 795 500 SH DFND 0 0 0 TEXAS ROADHOUSE INC COM 882681109 470 4900 SH DFND 0 0 0 TEXTRON INC COM 883203101 1726 30788 SH DFND 0 0 0 TEXTRON INC COM 883203101 289 5150 SH DFND 1 0 0 TFI INTL INC COM 87241L109 472 6300 SH DFND 0 0 0 TG THERAPEUTICS INC COM 88322Q108 36056 748048 SH DFND 0 0 0 TG THERAPEUTICS INC COM 88322Q108 14133 293223 SH DFND 1 0 0 THE TRADE DESK INC COM CL A 88339J105 7869 12075 SH DFND 0 0 0 THE TRADE DESK INC COM CL A 88339J105 5465 8386 SH DFND 1 0 0 THERAPEUTICSMD INC COM 88338N107 16 11800 SH DFND 0 0 0 THERAVANCE BIOPHARMA INC COM G8807B106 3578 175293 SH DFND 0 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 1224345 2682731 SH DFND 0 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 41869 91741 SH DFND 1 0 0 THOMSON REUTERS CORP. COM NEW 884903709 4597 52479 SH DFND 0 0 0 THOMSON REUTERS CORP. COM NEW 884903709 1100 12561 SH DFND 1 0 0 THOR INDS INC COM 885160101 579 4300 SH DFND 0 0 0 TILRAY INC COM CL 2 88688T100 239 10500 SH DFND 0 0 0 TIM S A SPONSORED ADR 88706T108 6210 2765787 SH DFND 0 0 0 TIM S A SPONSORED ADR 88706T108 2866 1276676 SH DFND 1 0 0 TIMKEN CO COM 887389104 414 5100 SH DFND 0 0 0 TJX COS INC NEW COM 872540109 32900 497357 SH DFND 0 0 0 TJX COS INC NEW COM 872540109 5147 77800 SH DFND 1 0 0 T-MOBILE US INC COM 872590104 237453 1895229 SH DFND 0 0 0 T-MOBILE US INC COM 872590104 29403 234677 SH DFND 1 0 0 TOLL BROTHERS INC COM 889478103 28305 498931 SH DFND 0 0 0 TOLL BROTHERS INC COM 889478103 2613 46067 SH DFND 1 0 0 TOPBUILD CORP COM 89055F103 170263 812985 SH DFND 0 0 0 TOPBUILD CORP COM 89055F103 1886 9005 SH DFND 1 0 0 TORM PLC SHS CL A G89479102 583 63786 SH DFND 0 0 0 TORM PLC SHS CL A G89479102 766 83934 SH DFND 1 0 0 TORO CO COM 891092108 233702 2265875 SH DFND 0 0 0 TORO CO COM 891092108 22300 216206 SH DFND 1 0 0 TORONTO DOMINION BK ONT COM NEW 891160509 41406 634936 SH DFND 0 0 0 TORONTO DOMINION BK ONT COM NEW 891160509 7784 119370 SH DFND 1 0 0 TRACTOR SUPPLY CO COM 892356106 82554 466192 SH DFND 0 0 0 TRACTOR SUPPLY CO COM 892356106 10944 61804 SH DFND 1 0 0 TRADEWEB MKTS INC CL A 892672106 2108 28480 SH DFND 0 0 0 TRADEWEB MKTS INC CL A 892672106 402 5433 SH DFND 1 0 0 TRANE TECHNOLOGIES PLC SHS G8994E103 77956 470861 SH DFND 0 0 0 TRANE TECHNOLOGIES PLC SHS G8994E103 3286 19848 SH DFND 1 0 0 TRANSDIGM GROUP INC COM 893641100 11401 19392 SH DFND 0 0 0 TRANSDIGM GROUP INC COM 893641100 2152 3660 SH DFND 1 0 0 TRANSOCEAN LTD REG SHS H8817H100 174 49100 SH DFND 0 0 0 TRANSPORTADORA DE GAS SUR SPONSORED ADS B 893870204 57 37400 SH DFND 0 0 0 TRANSUNION COM 89400J107 220166 2446285 SH DFND 0 0 0 TRANSUNION COM 89400J107 9059 100661 SH DFND 1 0 0 TRAVEL PLUS LEISURE CO COM 894164102 422 6900 SH DFND 0 0 0 TRAVELERS COMPANIES INC COM 89417E109 40911 272016 SH DFND 0 0 0 TRAVELERS COMPANIES INC COM 89417E109 3974 26421 SH DFND 1 0 0 TRAVERE THERAPEUTICS INC COM 89422G107 3250 130161 SH DFND 0 0 0 TREEHOUSE FOODS INC COM 89469A104 225 4300 SH DFND 0 0 0 TREX CO INC COM 89531P105 806 8800 SH DFND 0 0 0 TRI POINTE HOMES INC COM 87265H109 16641 817330 SH DFND 0 0 0 TRI POINTE HOMES INC COM 87265H109 1567 76971 SH DFND 1 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 7987 745788 SH DFND 0 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 3004 280476 SH DFND 1 0 0 TRIMBLE INC COM 896239100 328463 4222431 SH DFND 0 0 0 TRIMBLE INC COM 896239100 3153 40537 SH DFND 1 0 0 TRINET GROUP INC COM 896288107 273 3500 SH DFND 0 0 0 TRINITY INDS INC COM 896522109 205 7200 SH DFND 0 0 0 TRIP COM GROUP LTD ADS 89677Q107 92686 2338778 SH DFND 0 0 0 TRIP COM GROUP LTD ADS 89677Q107 34218 863447 SH DFND 1 0 0 TRIPADVISOR INC COM 896945201 50131 931967 SH DFND 0 0 0 TRIPADVISOR INC COM 896945201 128 2384 SH DFND 1 0 0 TRITON INTL LTD CL A G9078F107 297 5400 SH DFND 0 0 0 TRUIST FINL CORP COM 89832Q109 35499 608700 SH DFND 0 0 0 TRUIST FINL CORP COM 89832Q109 5104 87518 SH DFND 1 0 0 TURNING POINT THERAPEUTICS I COM 90041T108 56408 596341 SH DFND 0 0 0 TURNING POINT THERAPEUTICS I COM 90041T108 20797 219863 SH DFND 1 0 0 TUYA INC SPONSERED ADS 90114C107 27905 1320000 SH DFND 0 0 0 TWILIO INC CL A 90138F102 160664 471487 SH DFND 0 0 0 TWILIO INC CL A 90138F102 2999 8800 SH DFND 1 0 0 TWIST BIOSCIENCE CORP COM 90184D100 310 2500 SH DFND 0 0 0 TWITTER INC COM 90184L102 158643 2493213 SH DFND 0 0 0 TWITTER INC COM 90184L102 3658 57481 SH DFND 1 0 0 TWO HBRS INVT CORP COM NEW 90187B408 166 22700 SH DFND 0 0 0 TYLER TECHNOLOGIES INC COM 902252105 6207 14620 SH DFND 0 0 0 TYLER TECHNOLOGIES INC COM 902252105 1146 2700 SH DFND 1 0 0 TYSON FOODS INC CL A 902494103 8086 108832 SH DFND 0 0 0 TYSON FOODS INC CL A 902494103 7059 95007 SH DFND 1 0 0 UBER TECHNOLOGIES INC COM 90353T100 22058 404666 SH DFND 0 0 0 UBER TECHNOLOGIES INC COM 90353T100 15425 282977 SH DFND 1 0 0 UBS GROUP AG SHS H42097107 478574 30776146 SH DFND 0 0 0 UBS GROUP AG SHS H42097107 26422 1699120 SH DFND 1 0 0 UDR INC COM 902653104 53606 1222216 SH DFND 0 0 0 UDR INC COM 902653104 2722 62050 SH DFND 1 0 0 UFP INDUSTRIES INC COM 90278Q108 16842 222071 SH DFND 0 0 0 UFP INDUSTRIES INC COM 90278Q108 1602 21121 SH DFND 1 0 0 UGI CORP NEW COM 902681105 3766 91842 SH DFND 0 0 0 UGI CORP NEW COM 902681105 599 14600 SH DFND 1 0 0 ULTA BEAUTY INC COM 90384S303 7043 22782 SH DFND 0 0 0 ULTA BEAUTY INC COM 90384S303 1655 5353 SH DFND 1 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 569 5000 SH DFND 0 0 0 UMB FINL CORP COM 902788108 305 3300 SH DFND 0 0 0 UMPQUA HLDGS CORP COM 904214103 298 17000 SH DFND 0 0 0 UNDER ARMOUR INC CL C 904311206 633 34265 SH DFND 0 0 0 UNDER ARMOUR INC CL A 904311107 754 34042 SH DFND 0 0 0 UNIFIRST CORP MASS COM 904708104 224 1000 SH DFND 0 0 0 UNION PAC CORP COM 907818108 146346 663970 SH DFND 0 0 0 UNION PAC CORP COM 907818108 10133 45974 SH DFND 1 0 0 UNITED AIRLS HLDGS INC COM 910047109 1335 23200 SH DFND 0 0 0 UNITED AIRLS HLDGS INC COM 910047109 1590 27626 SH DFND 1 0 0 UNITED BANKSHARES INC WEST V COM 909907107 379 9830 SH DFND 0 0 0 UNITED CMNTY BKS BLAIRSVLE G COM 90984P303 239 7000 SH DFND 0 0 0 UNITED PARCEL SERVICE INC CL B 911312106 60617 356590 SH DFND 0 0 0 UNITED PARCEL SERVICE INC CL B 911312106 8216 48331 SH DFND 1 0 0 UNITED RENTALS INC COM 911363109 10720 32555 SH DFND 0 0 0 UNITED RENTALS INC COM 911363109 1882 5714 SH DFND 1 0 0 UNITED STATES STL CORP NEW COM 912909108 450 17200 SH DFND 0 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 37026 221357 SH DFND 0 0 0 UNITEDHEALTH GROUP INC COM 91324P102 357470 960761 SH DFND 0 0 0 UNITEDHEALTH GROUP INC COM 91324P102 69624 187126 SH DFND 1 0 0 UNITI GROUP INC COM 91325V108 184 16700 SH DFND 0 0 0 UNIVAR SOLUTIONS USA INC COM 91336L107 263 12200 SH DFND 0 0 0 UNIVAR SOLUTIONS USA INC COM 91336L107 16935 786222 SH DFND 1 0 0 UNIVERSAL DISPLAY CORP COM 91347P105 734 3100 SH DFND 0 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 3840 28794 SH DFND 0 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 634 4750 SH DFND 1 0 0 UNUM GROUP COM 91529Y106 967 34761 SH DFND 0 0 0 UPSTART HLDGS INC COM 91680M107 25413 197217 SH DFND 0 0 0 UPWORK INC COM 91688F104 242 5400 SH DFND 0 0 0 URBAN EDGE PPTYS COM 91704F104 141 8500 SH DFND 0 0 0 URBAN EDGE PPTYS COM 91704F104 284 17200 SH DFND 1 0 0 US BANCORP DEL COM NEW 902973304 34667 626775 SH DFND 0 0 0 US BANCORP DEL COM NEW 902973304 4926 89061 SH DFND 1 0 0 US ECOLOGY INC COM 91734M103 9649 231720 SH DFND 0 0 0 US ECOLOGY INC COM 91734M103 8570 205800 SH Call DFND 0 0 0 US ECOLOGY INC *W EXP 10/17/202 91734M111 8570 205800 SH Call DFND 0 0 0 US FOODS HLDG CORP COM 912008109 51119 1341010 SH DFND 0 0 0 UXIN LTD ADS 91818X108 67 57200 SH DFND 0 0 0 V F CORP COM 918204108 83210 1041167 SH DFND 0 0 0 V F CORP COM 918204108 2012 25169 SH DFND 1 0 0 VAIL RESORTS INC COM 91879Q109 5875 20145 SH DFND 0 0 0 VAIL RESORTS INC COM 91879Q109 1193 4089 SH DFND 1 0 0 VALE S A SPONSORED ADS 91912E105 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