X0306 4 2017-05-11 0 0001660719 Aralez Pharmaceuticals Inc. ARLZ 0001290976 Kirsch Arthur S C/O ARALEZ PHARMACEUTICALS INC., 7100 WEST CREDIT AVENUE, SUITE 101 MISSISSAUGA A6 L5N 0E4 ONTARIO, CANADA 1 0 0 0 Common Shares, without par value 2017-05-11 4 A 0 7500 0 A 156609 D Common Shares, without par value 5000 I By Trust Director Stock Option (right to buy) 1.56 2017-05-11 4 A 0 15000 0 A 2027-05-11 Common Stock, without par value 15000 15000 D Restricted Stock Units, all of which vest on May 11, 2018, subject to the director's continued service on the Board as of such date. Includes 149,109 shares of Common Stock and 7,500 Restricted Stock Units. The shares are held by the Laura A. Kirsch Trust, dated 4/12/2000 (the "Trust"), of which the Reporting Person is a trustee. Pursuant to General Instruction 4(b)(iv) to Form 4, all of the Issuer's securities held by the Trust are reported herein, and the Reporting Person expressly disclaims beneficial ownership of the securities held by the Trust, except to the extent of his pecuniary interest therein. The option vests in one installment on May 11, 2018, subject to the director's continued service on the Board as of such date. /s/ Eric L. Trachtenberg, attorney-in-fact for Arthur S. Kirsch 2017-05-12