X0306 4 2017-03-15 0 0001660719 Aralez Pharmaceuticals Inc. ARLZ 0001290976 Kirsch Arthur S C/O ARALEZ PHARMACEUTICALS INC., 7100 WEST CREDIT AVENUE, SUITE 101 MISSISSAUGA A6 L5N 0E4 ONTARIO, CANADA 1 0 0 0 Common Shares, without par value 2017-03-15 4 P 0 45000 2.2722 A 149109 D Common Shares, without par value 5000 I By Trust This transaction was executed in multiple trades at prices ranging from $2.11 to $2.53. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The shares are held by the Laura A. Kirsch Trust, dated 4/12/2000 (the "Trust"), of which the Reporting Person is a trustee. Pursuant to General Instruction 4(b)(iv) to Form 4, all of the Issuer's securities held by the Trust are reported herein, and the Reporting Person expressly disclaims beneficial ownership of the securities held by the Trust, except to the extent of his pecuniary interest therein. /s/ Eric L. Trachtenberg, attorney-in-fact for Arthur S. Kirsch 2017-03-17