X0306 4 2016-02-05 0 0001660719 Aralez Pharmaceuticals Inc. ARLZ 0001290976 Kirsch Arthur S C/O ARALEZ PHARMACEUTICALS INC. 2800 PARK PLACE 666 BURRARD STREET VANCOUVER A1 V6C2Z7 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2016-02-05 5 J 0 E 64719 0 A 64719 D Stock Option (Right to Buy) 13.26 2016-02-05 5 J 0 E 6107 0 A 2008-05-06 Common Shares 6107 6107 D Stock Option (Right to Buy) 11.83 2016-02-05 5 J 0 E 6107 0 A 2009-05-06 Common Shares 6107 6107 D Stock Option (Right to Buy) 6.35 2016-02-05 5 J 0 E 6107 0 A 2010-06-03 Common Shares 6107 6107 D Reflects the beneficial ownership of the reporting person following consummation of the business transaction among POZEN Inc. ("Pozen"), Tribute Pharmaceuticals Canada Inc. ("Tribute") and the Registrant on February 5, 2016, pursuant to the Agreement and Plan of Merger and Arrangement as entered into on June 8, 2015 and as amended on August 19, 2015 and December 7, 2015 among Pozen, Tribute, the Registrant, Aralez Pharmaceuticals Holdings Limited, ARLZ US Acquisition II Corp., and ARLZ CA Acquisition Corp. (the "Merger"). Includes 9,390 shares issuable pursuant to Restricted Stock Units previously granted by Pozen, predecessor to the Registrant. The option shall expire on the earlier of the third annual anniversary of the termination of the reporting person's services, or ten years following the date of grant. /s/ Eric L. Trachtenberg, attorney-in-fact for Arthur S. Kirsch 2016-02-09