The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 23,044 636,764 SH   DFND   636,764 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,092 722,233 SH   DFND   722,233 0 0
AGENUS INC COM NEW 00847G705 23,110 3,218,707 SH   DFND   3,218,707 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 1,833 263,921 SH   DFND   263,921 0 0
AMBARELLA INC SHS G037AX101 20,307 275,877 SH   DFND   275,877 0 0
ANTERO RES CORP COM 03674X106 10,063 373,413 SH   DFND   373,413 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 55,087 16,013,540 SH   DFND   0 16,013,540 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 18,788 2,556,256 SH   DFND   2,556,256 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,059 807,601 SH   DFND   807,601 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 1,974 81,400 SH   DFND   81,400 0 0
AVEXIS INC COM 05366U100 9,262 224,756 SH   DFND   224,756 0 0
AXOVANT SCIENCES LTD COM G0750W104 1,050,000 75,000,000 SH   DFND   0 75,000,000 0
BEIGENE LTD SPONSORED ADR 07725L102 5,238 170,000 SH   DFND   170,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 7,738 388,839 SH   DFND   388,839 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 12,391 133,933 SH   DFND   133,933 0 0
BLUEBIRD BIO INC COM 09609G100 3,999 59,002 SH   DFND   59,002 0 0
BRF SA SPONSORED ADR 10552T107 10,357 607,112 SH   DFND   607,112 0 0
CABOT OIL & GAS CORP COM 127097103 21,278 824,742 SH   DFND   824,742 0 0
CHINA ZENIX AUTO INTL LTD ADS 16951E104 5,813 6,074,805 SH   DFND   6,074,805 0 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 34,670 36,295,000 PRN   DFND   36,295,000 0 0
CTRIP COM INTL LTD NOTE 1.250%10/1 22943FAD2 32,437 25,000,000 PRN   DFND   25,000,000 0 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 14,166 13,000,000 PRN   DFND   13,000,000 0 0
DHT HOLDINGS INC DEBT 4.500%10/0 23335SAB2 15,172 17,000,000 PRN   DFND   17,000,000 0 0
EPIZYME INC COM 29428V104 8,368 850,446 SH   DFND   850,446 0 0
EQUITY COMWLTH COM SH BEN INT 294628102 20,550 680,000 SH   DFND   680,000 0 0
FIBROCELL SCIENCE INC COM NEW 315721209 335 465,672 SH   DFND   465,672 0 0
FITBIT INC CL A 33812L102 8,600 579,502 SH   DFND   579,502 0 0
FRONTLINE LTD SHS NEW G3682E192 2,930 408,341 SH   DFND   408,341 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 68,952 427,558 SH   DFND   427,558 0 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 20,225 1,118,340 SH   DFND   1,118,340 0 0
IMAX CORP COM 45245E109 4,908 169,400 SH   DFND   169,400 0 0
INTEL CORP COM 458140100 35,108 930,004 SH   DFND   930,004 0 0
INTEL CORP SDCV 12/1 458140AD2 21,557 15,500,000 PRN   DFND   15,500,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 15,123 91,881 SH   DFND   91,881 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 5,638 5,000,000 PRN   DFND   5,000,000 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 27,131 93,730 SH   DFND   93,730 0 0
JPMORGAN CHASE & CO COM 46625H100 7,325 110,000 SH   DFND   110,000 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 14,335 1,751,509 SH   DFND   1,751,509 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 39,612 1,794,024 SH   DFND   1,794,024 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 15,118 1,139,262 SH   DFND   1,139,262 0 0
MEDGENICS INC COM NEW 58436Q203 688 123,500 SH   DFND   123,500 0 0
MICROCHIP TECHNOLOGY INC SDCV 2.125%12/1 595017AB0 82,376 31,764,000 PRN   DFND   31,764,000 0 0
NEW YORK TIMES CO CL A 650111107 23,295 1,949,409 SH   DFND   1,949,409 0 0
NORDIC AMERICAN TANKERS LIMI COM G65773106 4,864 481,120 SH   DFND   481,120 0 0
NORDIC AMERICAN TANKERS LIMI COM G65773106 17,768 1,757,500 SH Put DFND   1,757,500 0 0
NORTHSTAR REALTY EUROPE CORP COM 66706L101 25,339 2,314,090 SH   DFND   2,314,090 0 0
NOVELLUS SYS INC NOTE 2.625% 5/1 670008AD3 56,518 20,193,000 PRN   DFND   20,193,000 0 0
OCERA THERAPEUTICS INC COM 67552A108 2,335 932,086 SH   DFND   932,086 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1,779 4,039,374 SH   DFND   4,039,374 0 0
PAYPAL HLDGS INC COM 70450Y103 14,101 344,190 SH   DFND   344,190 0 0
PDVWIRELESS INC COM 69290R104 18,466 902,599 SH   DFND   902,599 0 0
REGENXBIO INC COM 75901B107 5,197 370,943 SH   DFND   370,943 0 0
SAREPTA THERAPEUTICS INC COM 803607100 30,486 496,434 SH   DFND   496,434 0 0
SHIP FINANCE INTERNATIONAL L NOTE 3.250% 2/0 G81075AE6 43,674 40,500,000 PRN   DFND   40,500,000 0 0
SOLARCITY CORP COM 83416T100 7,957 406,816 SH   DFND   406,816 0 0
SOLARCITY CORP COM 83416T100 7,941 406,000 SH Put DFND   406,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 316,986 4,781,800 SH Put DFND   4,781,800 0 0
SPRAGUE RES LP COM UNIT REP LTD 849343108 844 39,979 SH   DFND   39,979 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 12,236 400,000 SH Put DFND   400,000 0 0
TAL ED GROUP NOTE 2.500% 5/1 874080AB0 78,913 29,000,000 PRN   DFND   29,000,000 0 0
TEEKAY TANKERS LTD CL A Y8565N102 9,247 3,654,776 SH   DFND   3,654,776 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 15,335 676,765 SH   DFND   676,765 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 2,014 334,206 SH   DFND   334,206 0 0
VERISIGN INC SDCV 3.250% 8/1 92343EAD4 79,419 34,600,000 PRN   DFND   34,600,000 0 0
WEBMD HEALTH CORP NOTE 2.500% 1/3 94770VAF9 11,490 11,000,000 PRN   DFND   11,000,000 0 0
WELLPOINT INC NOTE 2.750%10/1 94973VBG1 32,718 18,500,000 PRN   DFND   18,500,000 0 0
WELLS FARGO & CO NEW COM 949746101 11,291 255,000 SH   DFND   255,000 0 0
XENCOR INC COM 98401F105 8,740 356,873 SH   DFND   356,873 0 0
XILINX INC COM 983919101 12,871 236,855 SH   DFND   236,855 0 0
YY INC ADS REPCOM CLA 98426T106 10,160 190,700 SH   DFND   190,700 0 0
YY INC NOTE 2.250% 4/0 98426TAB2 4,950 5,000,000 PRN   DFND   5,000,000 0 0