The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 39,203 1,154,058 SH   DFND   1,154,058 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 55,941 7,389,810 SH   DFND   7,389,810 0 0
ADECOAGRO S A COM L00849106 1,140 120,800 SH   DFND   120,800 0 0
AGENUS INC COM NEW 00847G705 28,373 9,259,260 SH   DFND   9,259,260 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 5,915 129,100 SH   DFND   129,100 0 0
ALLY FINL INC COM 02005N100 18,813 800,375 SH   DFND   800,375 0 0
ALTISOURCE PORTFOLIO SOLNS S REG SHS L0175J104 24,549 214,254 SH   DFND   214,254 0 0
ALTISOURCE PORTFOLIO SOLNS S REG SHS L0175J104 19,100 166,700 SH Put DFND   166,700 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 19,965 1,126,039 SH   DFND   1,126,039 0 0
APPLE INC COM 037833100 10,204 109,800 SH   DFND   109,800 0 0
ARM HLDGS PLC SPONSORED ADR 042068106 9,957 220,100 SH Put DFND   220,100 0 0
ARMSTRONG WORLD INDS INC NEW COM 04247X102 16,235 282,685 SH   DFND   282,685 0 0
ARRAY BIOPHARMA INC COM 04269X105 9,559 2,096,200 SH   DFND   2,096,200 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 9,062 9,000,000 PRN   DFND   9,000,000 0 0
ARROWHEAD RESH CORP COM NEW 042797209 25,311 1,819,982 SH   DFND   1,819,982 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 9,253 725,734 SH   DFND   725,734 0 0
BLUEBIRD BIO INC COM 09609G100 14,140 366,600 SH   DFND   366,600 0 0
BRF SA SPONSORED ADR 10552T107 24,242 997,220 SH   DFND   997,220 0 0
CAPITAL ONE FINL CORP COM 14040H105 42,776 517,865 SH   DFND   517,865 0 0
CHINA ZENIX AUTO INTL LTD ADS 16951E104 9,783 6,074,805 SH   DFND   6,074,805 0 0
CLOVIS ONCOLOGY INC COM 189464100 8,685 209,735 SH   DFND   209,735 0 0
COMMONWEALTH REIT COM SH BEN INT 203233101 22,372 850,000 SH   DFND   850,000 0 0
CONNS INC COM 208242107 37,635 761,995 SH   DFND   761,995 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 15,935 248,823 SH   DFND   248,823 0 0
CUBIST PHARMACEUTICALS INC RIGHT 99/99/9999 229678123 66 572,366 SH   DFND   572,366 0 0
CYTRX CORP COM PAR $.001 232828509 19,311 4,619,900 SH   DFND   4,619,900 0 0
DHT HOLDINGS INC SHS NEW Y2065G121 28,134 3,907,497 SH   DFND   3,907,497 0 0
DYAX CORP COM 26746E103 21,059 2,193,600 SH   DFND   2,193,600 0 0
E TRADE FINANCIAL CORP NOTE 8/3 269246AZ7 53,898 26,214,000 PRN   DFND   26,214,000 0 0
E TRADE FINANCIAL CORP COM NEW 269246401 7,760 365,000 SH Call DFND   365,000 0 0
EBAY INC COM 278642103 53,154 1,061,800 SH   DFND   1,061,800 0 0
EBAY INC COM 278642103 6,252 124,900 SH Call DFND   124,900 0 0
ENDO HEALTH SOLUTIONS INC NOTE 1.750% 4/1 29264FAB2 24,028 10,000,000 PRN   DFND   10,000,000 0 0
EPIZYME INC COM 29428V104 31,419 1,009,600 SH   DFND   1,009,600 0 0
FIRST SOLAR INC COM 336433107 7,106 100,000 SH Put DFND   100,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 10,041 645,705 SH   DFND   645,705 0 0
GREEN DOT CORP CL A 39304D102 27,921 1,471,097 SH   DFND   1,471,097 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 45,014 4,556,090 SH   DFND   4,556,090 0 0
HOME LN SERVICING SOLUTIONS ORD SHS G6648D109 2,821 124,100 SH   DFND   124,100 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,006 4,251 SH   DFND   4,251 0 0
JA SOLAR HOLDINGS CO LTD SPON ADR REP5ORD 466090206 10,338 951,900 SH   DFND   951,900 0 0
JINKOSOLAR HLDG CO LTD SPONSORED ADR 47759T100 10,828 358,900 SH   DFND   358,900 0 0
JPMORGAN CHASE & CO COM 46625H100 19,808 343,770 SH   DFND   343,770 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 9,631 626,200 SH   DFND   626,200 0 0
LIBERTY INTERACTIVE CORP INT COM SER A 53071M104 18,626 634,400 SH   DFND   634,400 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 35,089 462,005 SH   DFND   462,005 0 0
LUMBER LIQUIDATORS HLDGS INC COM 55003T107 71,735 944,500 SH Put DFND   944,500 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 50,271 1,431,000 SH   DFND   1,431,000 0 0
MEDIVATION INC COM 58501N101 12,928 167,728 SH   DFND   167,728 0 0
MIRATI THERAPEUTICS INC COM 60468T105 9,949 507,184 SH   DFND   507,184 0 0
NATIONSTAR MTG HLDGS INC COM 63861C109 2,392 65,900 SH   DFND   65,900 0 0
NORTHSTAR RLTY FIN CORP COM 66704R100 38,610 2,224,858 SH   DFND   2,224,858 0 0
OCERA THERAPEUTICS INC COM 67552A108 5,062 694,227 SH   DFND   694,227 0 0
OCWEN FINL CORP COM NEW 675746309 37,842 1,020,000 SH Put DFND   1,020,000 0 0
OCWEN FINL CORP COM NEW 675746309 72,308 1,949,004 SH   DFND   1,949,004 0 0
ONCOTHYREON INC COM 682324108 18,238 5,628,899 SH   DFND   5,628,899 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 3,654 3,873,000 SH   DFND   3,873,000 0 0
PEREGRINE SEMICONDUCTOR CORP COM 71366R703 7,744 1,128,935 SH   DFND   1,128,935 0 0
PHH CORP COM NEW 693320202 20,008 870,659 SH   DFND   870,659 0 0
REALOGY HLDGS CORP COM 75605Y106 30,900 819,400 SH   DFND   819,400 0 0
REPROS THERAPEUTICS INC *W EXP 02/08/201 76028H126 10,280 708,969 SH   DFND   708,969 0 0
REPROS THERAPEUTICS INC *W EXP 02/08/201 76028H118 14,806 874,635 SH   DFND   874,635 0 0
RETROPHIN INC COM 761299106 26,530 2,287,583 SH   DFND   2,287,583 0 0
SALESFORCE COM INC NOTE 0.750% 1/1 79466LAB0 142,830 52,500,000 PRN   DFND   52,500,000 0 0
SBA COMMUNICATIONS CORP NOTE 4.000%10/0 78388JAM8 58,750 17,500,000 PRN   DFND   17,500,000 0 0
SCORPIO BULKERS INC SHS Y7546A106 6,428 722,210 SH   DFND   722,210 0 0
SOLARCITY CORP NOTE 2.750%11/0 83416TAA8 11,879 8,500,000 PRN   DFND   8,500,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1,300 88,600 SH   DFND   88,600 0 0
SUNCOKE ENERGY INC COM 86722A103 2,103 97,821 SH   DFND   97,821 0 0
SUNPOWER CORP DBCV 4.500% 3/1 867652AE9 27,743 15,000,000 PRN   DFND   15,000,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 15,215 711,300 SH Put DFND   711,300 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 73,308 1,561,742 SH   DFND   1,561,742 0 0
THE9 LTD ADR 88337K104 1,307 752,963 SH   DFND   752,963 0 0
UNITED THERAPEUTICS CORP DEL NOTE 1.000% 9/1 91307CAF9 18,883 10,000,000 PRN   DFND   10,000,000 0 0
VERASTEM INC COM 92337C104 1,498 165,396 SH   DFND   165,396 0 0
WALTER ENERGY INC COM 93317Q105 269 49,300 SH   DFND   49,300 0 0
WESCO INTL INC DBCV 6.000% 9/1 95082PAH8 58,636 19,000,000 PRN   DFND   19,000,000 0 0
XENCOR INC COM 98401F105 9,233 794,600 SH   DFND   794,600 0 0
YPF SOCIEDAD ANONIMA SPON ADR CL D 984245100 64,717 1,980,313 SH   DFND   1,980,313 0 0