Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Millions	1 Months Ended			3 Months Ended
	Aug. 31, 2021	Aug. 31, 2018	Oct. 31, 2016	Mar. 31, 2022	Nov. 30, 2020	Jan. 31, 2017
Asset Purchase Agreement [Member]
Loss Contingencies [Line Items]
Upfront payment paid		$ 3.0
Aggregate milestone payment				$ 190.0
Asset Purchase Agreement [Member] | Approval from FDA [Member]
Loss Contingencies [Line Items]
Milestone payment				25.0
AstraZeneca License Agreement [Member]
Loss Contingencies [Line Items]
Aggregate milestone payment	$ 208.0
Upfront payment	$ 8.0
CPF License Agreements [Member]
Loss Contingencies [Line Items]
Upfront payment			$ 7.0
Additional milestone payment payable				319.5
CPF License Agreements [Member] | Transfer of Phase 1 Clinical Trials [Member]
Loss Contingencies [Line Items]
Milestone payment						$ 2.0
CPF License Agreements [Member] | First patient first trial post amendment [Member]
Loss Contingencies [Line Items]
Milestone payment					$ 2.0
CPF License Agreement Amendment [Member]
Loss Contingencies [Line Items]
Additional milestone payment payable				$ 290.0