Subsequent Event - Additional Information (Detail)				1 Months Ended	12 Months Ended
	Mar. 07, 2022 USD ($) shares	Feb. 03, 2022 USD ($) shares	Jan. 21, 2022 USD ($) Tranche	Jan. 31, 2022 $ / shares shares	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 shares	Dec. 31, 2019 USD ($) shares
Subsequent Event [Line Items]
Proceeds from exercise of common stock warrants					$ 810,000
Proceeds from exercise of common stock options					$ 847,000		$ 445,000
Common Stock [Member]
Subsequent Event [Line Items]
Issuance of common stock, Shares | shares					4,316,968	732,752
Issuance of common stock for exercise of common stock options, Shares | shares					64,847		8,056
Subsequent Event [Member] | Former Employees and Non-discretionary Sales [Member]
Subsequent Event [Line Items]
Issuance of common stock for exercise of common stock options, Shares | shares	212,892
Proceeds from exercise of common stock options	$ 2,800,000
Subsequent Event [Member] | Series A [Member]
Subsequent Event [Line Items]
Issuance of common stock pertaining to warrant exercise | shares	18,937
Subsequent Event [Member] | Series B [Member]
Subsequent Event [Line Items]
Issuance of common stock pertaining to warrant exercise | shares	2,312,257
Subsequent Event [Member] | Series A and Series B Warrant [Member]
Subsequent Event [Line Items]
Proceeds from exercise of common stock warrants	$ 30,800,000
Subsequent Event [Member] | Underwritten Public Offering [Member]
Subsequent Event [Line Items]
Proceeds from issuance of common stock, net of deferred financing costs		$ 145,600,000
Underwriting discounts and commissions and offering expenses		$ 9,700,000
Subsequent Event [Member] | Underwritten Public Offering [Member] | Common Stock [Member]
Subsequent Event [Line Items]
Issuance of common stock, Shares | shares	4,824,075	750,000		4,074,075
Share issued price per share | $ / shares				$ 27.00
Subsequent Event [Member] | Underwritten Public Offering [Member] | Pre-funded Warrants to Purchase Common Stock [Member]
Subsequent Event [Line Items]
Number of securities called by warrants and rights | shares				925,925
Share issued price per share | $ / shares				$ 26.999
Oxford Finance, LLC [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Aggregate principal amount of loan			$ 125,000,000.0
Number of tranches | Tranche			4
Floating interest per annum			5.25%
Final payment fee			6.00%
Facility fee			0.50%
Oxford Finance, LLC [Member] | Subsequent Event [Member] | Floor Rate [Member]
Subsequent Event [Line Items]
Interest rate, stated percentage			8.50%
Oxford Finance, LLC [Member] | Before First Anniversary [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Accrued interest and the final payment fee subject to a prepayment fee			2.00%
Oxford Finance, LLC [Member] | After First and Before Third Anniversary [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Accrued interest and the final payment fee subject to a prepayment fee			1.00%
Oxford Finance, LLC [Member] | Term Loan C [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Aggregate principal amount of loan			$ 70,000.0
Line of credit facility expiration period			30 days
Line of credit facility expiration date			Dec. 31, 2023
Oxford Finance, LLC [Member] | Term Loan D [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Aggregate principal amount of loan			$ 50,000.0
Oxford Finance, LLC [Member] | Term Loan A [Member]
Subsequent Event [Line Items]
Loan agreement, description					Contemporaneously with executing the Loan Agreement, the Company drew down the first $5.0 million tranche (Term Loan A).
Gilead [Member] | Subsequent Event [Member] | Securities Purchase Agreement [Member]
Subsequent Event [Line Items]
Issuance of common stock pertaining to warrant exercise | shares	725,283
Proceeds from exercise of common stock warrants	$ 9,600,000
Term Loan A [Member] | Oxford Finance, LLC [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Proceeds from issuance of debt			$ 5,000,000.0