X0306 4 2016-01-20 0 0001290149 ProNAi Therapeutics Inc DNAI 0001647663 Rodigueza Wendi C/O PRONAI THERAPEUTICS, INC., 2150 885 WEST GEORGIA ST., VANCOUVER A1 V6C 3E8 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Scientific Officer Common Stock 2016-01-20 4 S 0 1000 9.59 D 158276 D Common Stock 2016-01-21 4 S 0 1000 10.323 D 157276 D Common Stock 2016-01-22 4 S 0 1000 9.66 D 156276 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.30 to $10.37 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Sukhi Jagpal as attorney-in-fact for Wendi Rodrigueza, Ph.D. 2016-01-22