X0206 3 2015-07-15 0 0001290149 ProNAi Therapeutics Inc DNAI 0001647647 Klencke Barbara C/O PRONAI THERAPEUTICS, INC. 2150 ? 885 WEST GEORGIA ST. VANCOUVER A1 V6C 3E8 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Development Officer Stock Option (right to buy) 6.705 2025-06-10 Common Stock 295302 D Stock Option (right to buy) 6.705 2025-06-10 Common Stock 174497 D The option vests as to 25% of the total shares on June 11, 2016, and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested and exercisable on June 11, 2019, subject to the reporting person's provision of service to the issuer on each vesting date. The option vests as to 25% of the total shares on June 11, 2016, and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested and exercisable on June 11, 2019, subject to the reporting person's provision of service to the issuer on each vesting date. The option is subject to accelerated vesting on certain conditions. /s/ Sukhi Jagpal as attorney-in-fact for Barbara Klencke, M.D. 2015-07-15