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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net loss $ (88,275) $ (53,335) $ (42,015)
Adjustments to reconcile net loss to net cash used in operating activities:      
Changes in fair value of warrant liabilities 20,926    
Securities issuance obligation 10,485    
Stock-based compensation 5,695 6,796 5,905
Warrant issuance costs 1,279    
Term loan repayment fee 438    
Depreciation and amortization 83 111 258
Other 161 (68) 31
Changes in operating assets and liabilities:      
Prepaid expenses and other assets 336 (1,341) (115)
Accrued, other and operating lease liabilities (2,034) 2,770 990
Accounts payable (277) (48) (1,217)
Net cash used in operating activities (51,183) (45,115) (36,163)
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchase of property and equipment (39) (118) (92)
Net cash used in investing activities (39) (118) (92)
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from public offering, net of offering costs 97,731    
Payment of term loan and repayment fee (5,438)    
Proceeds from exercise of common stock options 445 180 166
Proceeds from issuance of common stock upon follow-on offering, net of offering costs   45,996 27,422
Proceeds from issuance of term loan, net of issuance costs   4,955  
Net cash provided by financing activities 92,738 51,131 27,588
Effect of exchange rate changes on cash, cash equivalents and restricted cash (34) (88) (4)
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH 41,482 5,810 (8,671)
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—Beginning of period 106,346 100,536 109,207
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—End of period 147,828 106,346 100,536
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:      
Cash paid for (refund of) income taxes, net (69) 15 $ 260
Cash paid for interest 336 87  
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION:      
Right-of-use asset obtained in exchange for operating lease obligation 771    
Issuance costs of convertible voting preferred stock and warrants included in accrued and other liabilities $ 268    
Issuance of common stock warrant   $ 116