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Stock-Based Compensation - Schedule of Estimated Grant-date Fair Values of Stock-based Awards Using Black-Scholes Option Pricing Model Assumptions (Detail)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expected volatility, Minimum 88.00% 86.00% 88.00% 86.00%
Expected volatility, Maximum 91.00% 87.00% 91.00% 96.00%
Risk-free interest rate, Minimum 2.60% 1.80% 2.60% 1.80%
Risk-free interest rate, Maximum 2.90% 1.90% 2.90% 2.30%
Expected dividend rate 0.00% 0.00% 0.00% 0.00%
Minimum [Member]        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expected term (in years) 5 years 3 months 19 days 5 years 3 months 19 days 5 years 3 months 19 days 5 years 3 months 19 days
Maximum [Member]        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expected term (in years) 7 years 6 years 1 month 6 days 7 years 7 years