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Stock-Based Compensation - Schedule of Estimated Grant-date Fair Values of Stock-based Awards Using Black-Scholes Option Pricing Model Assumptions (Detail)
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected volatility, Minimum 89.00% 77.00%
Expected volatility, Maximum 96.00% 84.00%
Risk-free interest rate, Minimum 2.00% 1.30%
Risk-free interest rate, Maximum 2.30% 1.90%
Expected dividend rate 0.00% 0.00%
Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years) 5 years 4 months 24 days 5 years 4 months 24 days
Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years) 7 years 10 years