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Restructuring Costs (Tables)
 3 Months Ended
Mar. 31, 2017
Restructuring and Related Activities [Abstract]  
Summary of Restructuring Activities

The following table summarizes restructuring activities for the three months ended March 31, 2017:

 

     Contract
Termination		      Employee
Termination		      Total  
     (in thousands)  

Accrual balance at December 31, 2016

    $ 664      $ 99      $ 763  

Adjustments to research and development expense

      (45 )       —          (45 ) 

Cash payments

      (130 )       (93 )       (223 ) 
  

 

 

     

 

 

     

 

 

  

Accrual balance at March 31, 2017

    $ 489      $ 6      $ 495