Restructuring Costs (Tables)

9 Months Ended

Sep. 30, 2016

Restructuring and Related Activities [Abstract]

Summary of Restructuring Activities

The following table summarizes restructuring activities for the three months ended September 30, 2016:

	Contract Termination			Employee Termination			Asset Impairment		Total
	(in thousands)
Accrual balance at June 30, 2016	$	2,093		$	57		$	—	$	2,150
Adjustments to research and development expense		(420	)		—			—		(420	)
Restructuring costs charged to general and administrative expense		—			100			—		100
Cash payments		(254	)		(101	)		—		(355	)
Accrual balance at September 30, 2016	$	1,419		$	56		$	—	$	1,475

The following table summarizes restructuring activities for the nine months ended September 30, 2016:

	Contract Termination			Employee Termination			Asset Impairment			Total
	(in thousands)
Accrual balance at December 31, 2015	$	—		$	—		$	—		$	—
Restructuring costs charged to research and development expense		2,367			—			—			2,367
Restructuring costs charged to general and administrative expense		5			286			130			421
Non-cash charges		(681	)		—			(130	)		(811	)
Cash payments		(272	)		(230	)		—			(502	)
Accrual balance at September 30, 2016	$	1,419		$	56		$	—		$	1,475