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Income Taxes - Reconciliation Between Income Taxes Computed at the Federal Statutory Income Tax Rate and the Provision for Income Taxes (Detail)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Income Tax Disclosure [Abstract]      
Federal statutory rate 34.00% 34.00% 34.00%
Change in valuation allowance (27.80%) (37.30%) (23.10%)
Federal tax credit 2.60% 1.80% 1.80%
State income tax benefit, net of federal benefit 2.90% 4.00% 2.20%
Conversion costs     (13.50%)
Change in fair value of preferred stock warrants (11.10%) (2.00%) (1.10%)
Other permanent items (0.70%) (0.50%) (0.30%)
Total provision for income taxes (0.10%)