X0202 3 2004-05-06 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001289808 Negulescu Paul A C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 02139 0 1 0 0 VP, Research Common Stock 30766 D Common Stock 800 D Common Stock 1575 D Common Stock 20000 D Common Stock 1316 I 401(k) Stock Options 39.28 2001-10-18 2011-07-17 Common Stock 40000 D Stock Options 15.87 2002-10-22 2012-07-21 Common Stock 23433 D Stock Options 15.60 2007-04-18 2013-01-17 Common Stock 5286 D Stock Options 15.60 2003-04-18 2013-01-17 Common Stock 43568 D Stock Options 9.07 2004-03-11 2013-12-11 Common Stock 6000 D Stock Options 9.69 2004-06-17 2014-03-17 Common Stock 11813 D Stock Options 24.66 2005-06-11 2011-12-10 Common Stock 6366 D Stock Options 24.66 2002-03-11 2011-12-10 Common Stock 31766 D Stock Options 1.22 2001-02-01 2007-01-30 Common Stock 62 D Stock Options 8.47 2002-01-01 2008-01-01 Common Stock 1054 D Stock Options 8.47 2002-08-01 2008-08-01 Common Stock 1550 D Stock Options 10.39 2003-01-01 2009-01-01 Common Stock 1348 D Stock Options 12.50 2000-12-01 2009-03-01 Common Stock 10009 D Stock Options 10.84 2001-12-01 2009-04-01 Common Stock 1808 D Stock Options 19.16 2001-12-01 2009-12-01 Common Stock 6847 D Stock Options 58.88 2001-12-01 2010-02-01 Common Stock 5269 D Stock Options 104.79 2004-01-28 2010-09-28 Common Stock 830 D Stock Options 104.79 2001-09-28 2010-09-28 Common Stock 17769 D Stock Options 41.44 2004-01-12 2011-02-12 Common Stock 1038 D Stock Options 10.84 2000-12-01 2009-04-01 Common Stock 516 D Stock Options 19.16 2000-12-01 2009-12-01 Common Stock 8652 D Stock Options 41.44 2002-02-12 2011-02-12 Common Stock 23885 D Stock grant made under the Vertex 1996 Stock and Option Plan, vesting in 4 equal annual installments from 12/11/2003. Stock grant made under the Vertex 1996 Stock and Option Plan, vesting on 3/17/2008, subject to acceleration upon achievement of certain performance-based milestones. Stock grant made under the Vertex1996 Stock and Option Plan, vesting 50% on May 6, 2009, subject to acceleration upon achievement of a performance-based milestone based on Company profitability, and 50% on May 6, 2007. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 20 quarterly installments from 7/18/2001. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 20 quarterly installments from 7/22/2002. Right to buy under the Vertex 1996 Stock and Option Plan granted 1/18/2003 vesting in 8 quarterly installments from 4/18/2007. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 20 quarterly installments from 1/18/2003. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 16 quarterly installments from 12/11/2003. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 16 quarterly installments from 3/17/2004. Right to buy under the Vertex 1996 Stock and Option Plan granted 12/11/2001 vesting in 8 quarterly installments from 6/11/2005. Right to buy under the Vertex 1996 Stock and Option Plan vesting in 20 quarterly installments from 12/11/2001. Right to buy under the Aurora 1996 Stock Plan granted 1/30/1997 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 11/20/1998 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 11/20/1998 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 1/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 3/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 4/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 12/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 2/1/2000 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 9/28/2000 vests monthly from 1/28/2004. Right to buy under the Aurora 1996 Stock Plan granted 9/28/2000 vests monthly from 9/28/2001. Right to buy under the Aurora 1996 Stock Plan granted 2/12/2001 vests monthly from 1/12/2004. Right to buy under the Aurora 1996 Stock Plan granted 4/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 12/1/1999 is fully vested. Right to buy under the Aurora 1996 Stock Plan granted 2/12/2001 vests monthly from 2/12/2002. Valerie L. Andrews, Attorney-In-Fact 2004-05-10