X0303 4 2010-06-22 0 0001142596 NUVASIVE INC NUVA 0001289409 Miles Patrick 7475 LUSK BLVD. SAN DIEGO CA 92121 0 1 0 0 President, Americas Common Stock 2010-06-22 4 M 0 2500 23.24 A 5308 D Common Stock 2010-06-22 4 S 0 2500 38.4476 D 2808 D Common Stock 2010-06-22 4 M 0 2924 23.24 A 5732 D Common Stock 2010-06-22 4 S 0 2924 39.6284 D 2808 D Stock Option (Right to Buy) 23.24 2010-06-22 4 M 0 5424 0 D 2017-01-16 Common Stock 5424 57312 D The shares sold were acquired contemporaneously upon the cashless exercise of a stock option at an exercise price of $23.24 per share. The sale reported on this Form 4 was effected pursuant to a rule 10b5-1 trading plan adopted by the Reporting Person on May 19, 2009. 25% of the total shares subject to the option vested on January 16, 2008 which was the first anniversary of the date of grant; the remaining shares vest in 36 equal monthly installments thereafter. /s/ Jason Hannon, Attorney-in-fact 2010-06-24