Statements of Convertible Preferred Stock and Stockholders' Equity - USD ($)	Convertible Preferred Stock Series A [Member]	Convertible Preferred Stocks Series B [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Treasury Stock [Member]	Retained Earnings [Member]	Total
Beginning balance, value at Dec. 31, 2018	$ 5,960,475		$ 59,058	$ 478,179,574	$ (205,999)	$ (476,721,490)	$ 1,311,143
Beginning Balance, Shares at Dec. 31, 2018	23,900		59,058,297
Issuance of common stock			$ 7,779	13,312,405			13,320,184
Issuance of common stock, Shares			7,778,806
Share-based compensation			$ 207	1,811,877			1,812,084
Share-based compensation, Shares			207,212
Components of net loss						(4,591,284)	(4,591,284)
Employee stock purchase plan			$ 40	80,017			80,057
Employee stock purchase plan, Shares			39,648
Preferred stock issuance		$ 5,610		10,626,328			10,631,938
Preferred stock issuance, shares		5,610,121
Preferred stock conversion	$ (202,285)		$ 1,446	200,839			202,285
Preferred stock conversion, Shares	(790)		1,445,660
Ending balance, value at Dec. 31, 2019	$ 5,758,190	$ 5,610	$ 68,530	504,211,040	(205,999)	(481,312,774)	22,766,407
Ending Balance, Shares at Dec. 31, 2019	23,110	5,610,121	68,529,623
Issuance of common stock			$ 3,863	15,057,950			15,061,813
Issuance of common stock, Shares			3,863,314
Share-based compensation			$ 149	3,169,199			3,169,348
Share-based compensation, Shares			147,989
Components of net loss						(6,646,459)	(6,646,459)
Employee stock purchase plan			$ 32	119,910			119,942
Employee stock purchase plan, Shares			32,467
Preferred stock conversion	$ (152,867)		$ 1,120	151,747			152,867
Preferred stock conversion, Shares	(597)		1,120,810
Ending balance, value at Dec. 31, 2020	$ 5,605,323	$ 5,610	$ 73,694	$ 522,709,846	$ (205,999)	$ (487,959,233)	$ 34,623,918
Ending Balance, Shares at Dec. 31, 2020	22,513	5,610,121	73,694,203