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Statements of Convertible Preferred Stock and Stockholders' Equity (Unaudited) - USD ($)
Convertible Preferred Stock Series A [Member]
Convertible Preferred Stock Series B [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2018 $ 5,960,475 $ 59,058 $ 478,179,574 $ (205,999) $ (476,721,490) $ 1,311,143
Beginning Balance, Shares at Dec. 31, 2018 23,900 (0) 59,058,297        
Issuance of common stock and warrants     $ 47 (50,479)     (50,432)
Issuance of common stock and warrants, Shares     46,484        
Share-based compensation     $ 174 954,808     954,982
Share-based compensation, shares     174,462        
Components of net loss           $ (3,550,538) (3,550,538)
Employee stock purchase plan     $ 24 $ 31,934     $ 31,958
Employee stock purchase plan, Shares     23,757        
Issuance of common stock, Shares  
Preferred stock conversion $ (11,522) $ 80 $ 11,442   $ 11,522
Preferred stock conversion, shares (45) 80,038        
Ending balance, value at Jun. 30, 2019 $ 5,948,953 $ 59,383 479,127,279 (205,999) $ (480,272,028) (1,291,365)
Ending Balance, Shares at Jun. 30, 2019 23,855 (0) 59,383,038        
Beginning balance, value at Mar. 31, 2019 $ 5,955,354 $ 59,308 478,363,886 (205,999) (478,844,310) (627,115)
Beginning Balance, Shares at Mar. 31, 2019 23,880 59,308,237        
Issuance of common stock and warrants     $ 14 (66,869)     (66,855)
Issuance of common stock and warrants, Shares     13,397        
Share-based compensation     $ 7 807,021     807,028
Share-based compensation, shares     7,500        
Components of net loss           (1,427,718) (1,427,718)
Employee stock purchase plan     $ 9 16,885     16,894
Employee stock purchase plan, Shares     9,132        
Issuance of common stock    
Issuance of common stock, Shares            
Preferred stock conversion $ (6,401) $ 45 6,356     6,401
Preferred stock conversion, shares (25) 44,772        
Ending balance, value at Jun. 30, 2019 $ 5,948,953 $ 59,383 479,127,279 (205,999) (480,272,028) (1,291,365)
Ending Balance, Shares at Jun. 30, 2019 23,855 (0) 59,383,038        
Beginning balance, value at Dec. 31, 2019 $ 5,758,190 $ 5,610 $ 68,530 504,211,040 $ (205,999) (481,312,774) 22,766,407
Beginning Balance, Shares at Dec. 31, 2019 23,110 5,610,121 68,529,623        
Issuance of common stock and warrants     $ 3,815 15,004,554     15,008,369
Issuance of common stock and warrants, Shares     3,815,092        
Share-based compensation     $ 117 1,657,604     1,657,721
Share-based compensation, shares     116,989        
Components of net loss           $ (3,892,637) (3,892,637)
Employee stock purchase plan     $ 18 $ 65,006     $ 65,024
Employee stock purchase plan, Shares     17,835        
Issuance of common stock, Shares  
Preferred stock conversion $ (76,049) $ 551 $ 75,498   $ 76,049
Preferred stock conversion, shares (297) 551,285        
Ending balance, value at Jun. 30, 2020 $ 5,682,141 $ 5,610 $ 73,031 521,013,702 (205,999) $ (485,205,411) 35,680,933
Ending Balance, Shares at Jun. 30, 2020 22,813 5,610,121 73,030,824        
Beginning balance, value at Mar. 31, 2020 $ 5,709,027 $ 5,610 $ 69,041 504,990,377 (205,999) (483,284,305) 21,574,724
Beginning Balance, Shares at Mar. 31, 2020 22,918 5,610,121 69,040,781        
Share-based compensation     $ 8 935,401     935,409
Share-based compensation, shares     7,500        
Components of net loss           (1,921,106) (1,921,106)
Employee stock purchase plan     $ 11 32,790     32,801
Employee stock purchase plan, Shares     11,429        
Issuance of common stock     $ 3,774 15,028,445     15,032,219
Issuance of common stock, Shares     3,774,276        
Preferred stock conversion $ (26,886) $ 197 26,689   26,886
Preferred stock conversion, shares (105) 196,838        
Ending balance, value at Jun. 30, 2020 $ 5,682,141 $ 5,610 $ 73,031 $ 521,013,702 $ (205,999) $ (485,205,411) $ 35,680,933
Ending Balance, Shares at Jun. 30, 2020 22,813 5,610,121 73,030,824