144 0001288859 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 ROBERT BLUM Director Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

52500 4472475.00 124432565 07/01/2026 NASDAQ Common 07/01/2026 Exercise of Stock Options Issuer N 44990 07/01/2026 Cash Common 03/14/2025 Restricted Stock Units Issuer N 7510 03/14/2025 N/A N 10b5-1 Sales for ROBERT BLUM

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 06/15/2026 7500 528484.50 10b5-1 Sales for ROBERT BLUM

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 05/27/2026 7500 579065.25 10b5-1 Sales for ROBERT BLUM

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 05/14/2026 7500 584433.75 10b5-1 Sales for ROBERT BLUM

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 04/29/2026 7500 447176.25 10b5-1 Sales for ROBERT BLUM

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 04/15/2026 7500 490362.00 The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale. 07/01/2026 12/24/2025 /s/ Robert Blum