144 0001288859 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 Oyster Point Blvd. South San Francisco CA 94080 (650) 624-3000 ROBERT BLUM Officer Director Common E*TRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

12500 470830.00 95640600 05/31/2023 NASD COMMON 05/31/2023 Stock Option Exercise ISSUER N 12500 05/31/2023 Cash N ROBERT BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 05/16/2023 12500 467630.00 ROBERT BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 04/28/2023 12500 471008.75 ROBERT I. BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 04/14/2023 12500 445147.50 ROBERT BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 03/28/2023 12500 438077.00 ROBERT BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 03/15/2023 12500 465689.00 ROBERT BLUM

350 Oyster Point Blvd. South San Francisco CA 94080

Common 03/06/2023 12500 499277.00 05/31/2023 12/27/2022 /s/ Robert Ian Blum