<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001846877</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001288847</own:issuerCik>
      <own:issuerName>Five9, Inc.</own:issuerName>
      <own:secFileNumber>001-36383</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>3001 BISHOP DR., STE. #350</com:street1>
        <com:city>San Ramon</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94583</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>925-201-2000</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Leena Mansharamani</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Officer</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Morgan Stanley Smith Barney LLC</own:name>
        <own:address>
          <com:street1>Executive Financial Services</com:street1>
          <com:street2>1 New York Plaza 8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>2573</own:noOfUnitsSold>
      <own:aggregateMarketValue>64404.92</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>74723569</own:noOfUnitsOutstanding>
      <own:approxSaleDate>06/04/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/03/2026</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>RSU</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>2573</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/03/2026</own:paymentDate>
      <own:natureOfPayment>Not Applicable</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Leena Mansharamani</own:name>
        <own:address>
          <com:street1>3001 Bishop Drive</com:street1>
          <com:street2>Suite 350</com:street2>
          <com:city>San Ramon</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94583</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/04/2026</own:saleDate>
      <own:amountOfSecuritiesSold>1926</own:amountOfSecuritiesSold>
      <own:grossProceeds>34417.62</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:remarks>The sale reported on this Form 144 represents an Issuermandated sale by the Reporting Person to cover taxwithholding obligations in connection with the vesting andsettlement of Restricted Stock Units, and it does notrepresent a discretionary trade by the Reporting Person.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>06/03/2026</own:noticeDate>
      <own:signature>Leena Mansharamani</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
