<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001940974</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001288847</issuerCik>
<issuerName>Five9, Inc.</issuerName>
<secFileNumber>001-36383</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
<city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
</issuerAddress>
<issuerContactPhone>925-201-2000</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Panos Kozanian</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza </street1>
<street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
<city xmlns="http://www.sec.gov/edgar/common">New York</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>7008</noOfUnitsSold>
<aggregateMarketValue>329376.00</aggregateMarketValue>
<noOfUnitsOutstanding>74219203</noOfUnitsOutstanding>
<approxSaleDate>06/04/2024</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>06/03/2024</acquiredDate>
<natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>7008</amountOfSecuritiesAcquired>
<paymentDate>06/03/2024</paymentDate>
<natureOfPayment>Not Applicable</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<securitiesSoldInPast3Months>
<sellerDetails>
<name>Panos Kozanian</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
<city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
</address>
</sellerDetails>
<securitiesClassTitle>Common</securitiesClassTitle>
<saleDate>03/04/2024</saleDate>
<amountOfSecuritiesSold>8994</amountOfSecuritiesSold>
<grossProceeds>560506.08</grossProceeds>
</securitiesSoldInPast3Months>
<securitiesSoldInPast3Months>
<sellerDetails>
<name>Panos Kozanian</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
<city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
</address>
</sellerDetails>
<securitiesClassTitle>Common</securitiesClassTitle>
<saleDate>03/05/2024</saleDate>
<amountOfSecuritiesSold>2298</amountOfSecuritiesSold>
<grossProceeds>135972.66</grossProceeds>
</securitiesSoldInPast3Months>
<noticeSignature>
<noticeDate>06/03/2024</noticeDate>
<signature>Panos Kozanian</signature>
</noticeSignature>
</formData>
</edgarSubmission>
