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                               November 7, 2023

       R. Steven Hamner
       Chief Financial Officer
       Medical Properties Trust, Inc.
       MPT Operating Partnership, L.P.
       1000 Urban Center Drive, Suite 501
       Birmingham, AL 35242

                                                        Re: Medical Properties
Trust, Inc.
                                                            MPT Operating
Partnership, L.P.
                                                            Form 10-K for the
Year Ended December 31, 2022
                                                            File No. 001-32559

       Dear R. Steven Hamner:

              We have reviewed your July 18, 2023 response to our comment
letter and have the
       following comments.

              Please respond to this letter within ten business days by
providing the requested
       information or advise us as soon as possible when you will respond. If
you do not believe a
       comment applies to your facts and circumstances, please tell us why in
your response.

              After reviewing your response to this letter, we may have
additional comments. Unless
       we note otherwise, any references to prior comments are to comments in
our July 3, 2023 letter.

       Form 10-K for the year ended December 31, 2022

       Significant Tenants
       Total Assets by Operator, page 13

   1.                                                   We note your response
to our prior comment 1 wherein you stated that at December 31,
                                                        2022, total assets of
your top five operators are generally comprised of real estate assets,
                                                        mortgage loans,
investments in unconsolidated real estate joint ventures, investments in
                                                        unconsolidated
operating entities, and other loans. We note your inclusion of a table
                                                        labeled total assets by
operator on page 21 of your Form 10-Q for the quarterly period
                                                        ended June 30, 2023.
However, we are unable to locate disclosure clarifying the nature of
                                                        the assets that are
associated with an operator (i.e. real estate assets, mortgage loans,
                                                        investments in
unconsolidated real estate joint ventures, investments in unconsolidated
                                                        operating entities, and
other loans). Please confirm that in future periodic filings you will
                                                        include the previously
requested disclosure clarifying the nature of the assets associated
 R. Steven Hamner
Medical Properties Trust, Inc.
November 7, 2023
Page 2
       with an operator, or tell us why you believe such clarifying disclosure
is not necessary.
2.     Please tell us when you expect to amend your Form 10-K for the fiscal
year ended
       December 31, 2022 to include audited financial statements of Steward
Health Care
       System LLC as of and for the year ended December 31, 2022.
       Please contact Jennifer Monick at 202-551-3295 or Mark Rakip at
202-551-3573 if you
have questions regarding comments on the financial statements and related
matters.



                                                             Sincerely,
FirstName LastNameR. Steven Hamner
                                                             Division of
Corporation Finance
Comapany NameMedical Properties Trust, Inc.
                                                             Office of Real
Estate & Construction
November 7, 2023 Page 2
cc:       Kevin Hanna
FirstName LastName