X0306 4 2019-09-19 0 0001717452 Odonate Therapeutics, Inc. ODT 0001287235 TIDMARSH GEORGE F C/O ODONATE THERAPEUTICS, INC. 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 1 0 0 0 Common Stock 2019-09-19 4 M 0 77331 0.00 A 77331 D Common Stock 2019-09-19 4 M 0 73960 0.00 A 151291 D Incentive Units 0.54 2019-09-19 4 M 0 78821 0.00 D Common Stock 78821 43225 D Incentive Units 0.54 2019-09-19 4 M 0 75385 0.00 D Common Stock 75385 49391 D The Reporting Person received 77,331 shares of common stock on exercise of incentive units, pursuant to the terms of the Odonate Management Holdings, LLC Equity Incentive Plan. The Reporting Person received 73,960 shares of common stock on exercise of incentive units, pursuant to the terms of the Odonate Management Holdings, LLC Equity Incentive Plan. The incentive units vested with respect to 25% of the underlying shares on 12/30/2017, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The incentive units do not expire. The incentive units vested with respect to 25% of the underlying shares on 3/2/2018, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ John Lemkey, as attorney-in-fact for George Tidmarsh 2019-09-23