CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($) $ in Thousands	Common Stock	Additional Paid-in Capital Cumulative effect adjustment	Additional Paid-in Capital	Accumulated Deficit Cumulative effect adjustment	Accumulated Deficit	Cumulative effect adjustment	Total
Balance at Dec. 31, 2020	$ 616	$ (70,779)	$ 751,304	$ (4,697)	$ (872,672)	$ (75,476)	$ (120,752)
Balance (in shares) at Dec. 31, 2020	61,671,231
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options and warrants	$ 6		6,327				6,333
Exercise of stock options and warrants (in shares)	580,781
At the market offering costs			(241)				(241)
Stock-based compensation expense			3,271				3,271
Net loss					(35,090)		(35,090)
Balance at Mar. 31, 2021	$ 622		689,882		(912,459)		(221,955)
Balance (in shares) at Mar. 31, 2021	62,252,012
Balance at Dec. 31, 2020	$ 616	$ (70,779)	751,304	$ (4,697)	(872,672)	$ (75,476)	(120,752)
Balance (in shares) at Dec. 31, 2020	61,671,231
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss							(86,386)
Balance at Sep. 30, 2021	$ 625		700,433		(963,755)		(262,697)
Balance (in shares) at Sep. 30, 2021	62,542,268
Balance at Mar. 31, 2021	$ 622		689,882		(912,459)		(221,955)
Balance (in shares) at Mar. 31, 2021	62,252,012
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options	$ 2		1,133				1,135
Exercise of stock options (in shares)	238,928
Stock-based compensation expense			3,117				3,117
Net loss					(28,593)		(28,593)
Balance at Jun. 30, 2021	$ 624		694,132		(941,052)		(246,296)
Balance (in shares) at Jun. 30, 2021	62,490,940
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options	$ 1		607				608
Exercise of stock options (in shares)	51,328
Stock-based compensation expense			5,694				5,694
Net loss					(22,703)		(22,703)
Balance at Sep. 30, 2021	$ 625		700,433		(963,755)		(262,697)
Balance (in shares) at Sep. 30, 2021	62,542,268
Balance at Dec. 31, 2021	$ 626		706,288		(683,134)		23,780
Balance (in shares) at Dec. 31, 2021	62,628,855
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options	$ 1		413				414
Exercise of stock options (in shares)	101,160
Stock-based compensation expense			3,892				3,892
Net loss					(33,011)		(33,011)
Balance at Mar. 31, 2022	$ 627		710,593		(716,145)		(4,925)
Balance (in shares) at Mar. 31, 2022	62,730,015
Balance at Dec. 31, 2021	$ 626		706,288		(683,134)		$ 23,780
Balance (in shares) at Dec. 31, 2021	62,628,855
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options (in shares)							101,160
Net loss							$ (81,316)
Balance at Sep. 30, 2022	$ 627		717,509		(764,450)		(46,314)
Balance (in shares) at Sep. 30, 2022	62,730,015
Balance at Mar. 31, 2022	$ 627		710,593		(716,145)		(4,925)
Balance (in shares) at Mar. 31, 2022	62,730,015
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation expense			3,072				3,072
Net loss					(30,849)		(30,849)
Balance at Jun. 30, 2022	$ 627		713,665		(746,994)		(32,702)
Balance (in shares) at Jun. 30, 2022	62,730,015
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation expense			3,844				3,844
Net loss					(17,456)		(17,456)
Balance at Sep. 30, 2022	$ 627		$ 717,509		$ (764,450)		$ (46,314)
Balance (in shares) at Sep. 30, 2022	62,730,015