CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net loss	$ (63,860)	$ (63,683)
Adjustments to reconcile net loss to net cash used in operating activities:
Early termination of operating lease	(454)
Stock-based compensation expense	6,964	6,388
Non-cash interest expense	900	822
Depreciation and amortization	469	745
Changes in operating assets and liabilities:
Receivables	23,676	(27,997)
Prepaid expenses and other assets	(3,668)	6,010
OMIDRIA contract royalty asset	13,964
Accounts payable and accrued expense	(12,653)	9,869
Net cash used in operating activities	(34,662)	(67,846)
Investing activities:
Purchases of investments	(103,169)	(4)
Proceeds from the sale and maturities of investments	51,200	63,500
Purchases of property and equipment	(103)	(100)
Net cash provided by (used in) investing activities	(52,072)	63,396
Financing activities:
Proceeds upon exercise of stock options and warrants	414	7,468
Payments on finance lease obligations	(352)	(576)
At the market offering costs		(241)
Net cash provided by financing activities	62	6,651
Net decrease in cash and cash equivalents	(86,672)	2,201
Cash and cash equivalents at beginning of period	100,808	10,501
Cash and cash equivalents at end of period	14,136	12,702
Supplemental cash flow information
Cash paid for interest	8,998	9,012
Property acquired under finance lease	$ 557	$ 39