<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001285819</cik>
        <entityName>OMEROS CORP</entityName>
        <issuerAddress>
            <street1>1420 5TH AVE</street1>
            <street2>SUITE 2600</street2>
            <city>SEATTLE</city>
            <stateOrCountry>WA</stateOrCountry>
            <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
            <zipCode>98101</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>206-676-5000</issuerPhoneNumber>
        <jurisdictionOfInc>WASHINGTON</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GREGORY</firstName>
                <middleName>A</middleName>
                <lastName>DEMOPULOS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MARCIA</firstName>
                <middleName>S.</middleName>
                <lastName>KELBON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RAY</firstName>
                <lastName>ASPIRI</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <middleName>J</middleName>
                <lastName>CABLE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>PETER</firstName>
                <middleName>A</middleName>
                <lastName>DEMOPULOS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>LEROY</firstName>
                <middleName>E.</middleName>
                <lastName>HOOD</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DANIEL</firstName>
                <middleName>K</middleName>
                <lastName>SPIEGELMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JEAN-PHILIPPE</firstName>
                <lastName>TRIPET</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1420 5TH AVE</street1>
                <street2>SUITE 2600</street2>
                <city>SEATTLE</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <yetToOccur>true</yetToOccur>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>REEDLAND CAPITAL PARTNERS</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>FINANCIAL WEST GROUP</associatedBDName>
                <associatedBDCRDNumber>16668</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>30 SUNNYSIDE AVENUE</street1>
                    <city>MILL VALLEY</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>94941</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>40000000</totalOfferingAmount>
            <totalAmountSold>0</totalAmountSold>
            <totalRemaining>40000000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>0</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>200000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Proceeds are to be used for general corporate purposes.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OMEROS CORP</issuerName>
                <signatureName>/s/ Gregory A. Demopulos</signatureName>
                <nameOfSigner>Gregory A. Demopulos</nameOfSigner>
                <signatureTitle>President, CEO, Chairman of the Board of Directors</signatureTitle>
                <signatureDate>2010-08-13</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
