<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001385702</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Common Stock, $0.01 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001285550</issuerCik>
        <issuerName>ClearPoint Neuro, Inc.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>18507C103</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>120 S. SIERRA AVENUE</com:street1>
          <com:street2>SUITE 100</com:street2>
          <com:city>SOLANA BEACH</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92075</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>MAK CAPITAL ONE LLC</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2375861.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2375861.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2375861.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>7.8</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <comments>The calculation is based upon 2,375,861 shares of Common Stock beneficially owned as of 06/30/2026 and a total of 30,504,227 shares of Common Stock, $0.01 par value per share, outstanding as of July 27, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 3, 2026.
</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>MAK Capital Fund LP</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>D0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2375861.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2375861.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2375861.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>7.8</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>The calculation is based upon 2,375,861 shares of Common Stock beneficially owned as of 06/30/2026 and a total of 30,504,227 shares of Common Stock, $0.01 par value per share, outstanding as of July 27, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 3, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Kaufman Michael A</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2375861.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2375861.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2375861.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>7.8</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>The calculation is based upon 2,375,861 shares of Common Stock beneficially owned as of 06/30/2026 and a total of 30,504,227 shares of Common Stock, $0.01 par value per share, outstanding as of July 27, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 3, 2026.
</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>ClearPoint Neuro, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>120 S. SIERRA AVENUE, SUITE 100, SOLANA BEACH, CALIFORNIA, 92075</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This Schedule 13G/A is being filed by:
i. MAK Capital Fund LP ("MAK Fund")
ii. MAK Capital One L.L.C. ("MAK Capital"); and
iii. Michael A. Kaufman ("Mr. Kaufman," and collectively with MAK Fund and MAK Capital, the "Reporting Persons")</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address of (i) MAK Fund is c/o Wakefield Quin, Victoria Place, 31 Victoria Street, Bermuda; and (ii) MAK Capital and Mr. Kaufman is 590 Madison Avenue, 31st Floor, New York, NY 10022.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>MAK Capital Fund LP is a Bermuda limited partnership. MAK Capital One L.L.C. is a Delaware limited liability company. Mr. Kaufman is a United States citizen.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>2,375,861</amountBeneficiallyOwned>
        <classPercent> 7.8%
The calculation is based upon 2,375,861 shares of Common Stock beneficially owned as of 06/30/2026 and a total of 30,504,227 shares of Common Stock, $0.01 par value per share, outstanding as of July 27, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 3, 2026.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>2,375,861</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>2,375,861</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>MAK CAPITAL ONE LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Managing Member</title>
        <date>08/12/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>MAK Capital Fund LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Managing Member</title>
        <date>08/12/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Kaufman Michael A</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Michael A. Kaufman</title>
        <date>08/12/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
