<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001284038</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001447669</issuerCik>
      <issuerName>TWILIO INC</issuerName>
      <secFileNumber>001-37806</secFileNumber>
      <issuerAddress>
        <com:street1>101 SPEAR STREET</com:street1>
        <com:street2>SUITE 500</com:street2>
        <com:city>San Francisco</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94105</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>415-390-2337</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROTTENBERG ERIKA</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>4100</noOfUnitsSold>
      <aggregateMarketValue>492118.00</aggregateMarketValue>
      <noOfUnitsOutstanding>152674214</noOfUnitsOutstanding>
      <approxSaleDate>06/02/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/15/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse - See Remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>TWILIO INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4100</amountOfSecuritiesAcquired>
      <paymentDate>08/15/2018</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares sold in this filing acquired and paid for between 08/15/2028 and 12/15/2025. Sold in the ERIKA ROTTENBERG REVOCABLE TRUST.</remarks>
    <noticeSignature>
      <noticeDate>06/02/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/27/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>ERIKA ROTTENBERG TTEE</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
