X0306 4 2018-06-14 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001283535 PATOU GARY C/O XENON PHARMACEUTICALS INC 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2018-06-14 4 M 0 8230 3.70 A 20258 D Common Shares 2018-06-14 4 F 0 2856 8.30 D 17402 D Common Shares 12500 I See Note Stock Option (Right to Buy) 3.70 2018-06-14 4 M 0 8230 0.00 D 2018-06-26 Common Shares 8230 0 D The exercise price was converted to U.S. dollars from $3.74 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the day of exercise. Represents the closing price of the Company's common shares in U.S. dollars on June 13, 2018, which was converted to a Canadian dollar amount for purposes of net settlement calculations. By Gary & Karen Barbara Patou TTEE Patou Family Trust FBO Gary Patou Karen Barbara Patou. The shares subject to the option fully vested on May 31, 2011. /s/ Joanne Smartt, Attorney-in-fact 2018-06-15