X0306 4 2017-02-13 0 0001557421 Ignyta, Inc. RXDX 0001283290 Lim Jonathan E C/O IGNYTA, INC. 4545 TOWNE CENTRE COURT SAN DIEGO CA 92121 1 1 1 0 President, CEO & Director Common Stock 2017-02-13 4 M 0 6945 0.60 A 130333 D Common Stock 3350000 I By City Hill Venture Partners I, LLC Stock Option (Right to Buy) 0.60 2017-02-13 4 M 0 6945 0.00 D 2017-02-13 2023-02-14 Common Stock 6945 0 D The Reporting Person is the Manager of City Hill Ventures, LLC, which is the Manager of City Hill Ventures Partners I, LLC, and as such the Reporting Person and City Hill Ventures, LLC have the power to vote or dispose of the securities held of record by the Reporting Person and may be deemed to beneficially own those securities. The Reporting Person disclaims beneficial ownership of the securities held of record by the City Hill Venture Partners I, LLC except to the extent of his pecuniary interest therein. /s/ Jonathan E. Lim 2017-03-10