X0306 4/A 2017-12-22 2017-12-22 0 0001557421 Ignyta, Inc. RXDX 0001283290 Lim Jonathan E C/O IGNYTA, INC. 4545 TOWNE CENTRE COURT SAN DIEGO CA 92121 1 1 0 0 President, CEO & Director Common Stock 2017-12-22 4 A 0 68334 0.00 A 198667 D Common Stock 3350000 I By City Hill Venture Partners I, LLC Represents the grant of restricted stock units to the Reporting Person. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units will vest as to 25% of the shares underlying each award on each anniversary of the Grant Date, subject to the Reporting Person's continues service with the Company through the vesting date. The Reporting Person is the Manager of City Hill Ventures, LLC, which is the Manager of City Hill Ventures Partners I, LLC, and as such the Reporting Person and City Hill Ventures, LLC have the power to vote or dispose of the securities held of record by the Reporting Person and may be deemed to beneficially own those securities. The Reporting Person disclaims beneficial ownership of the securities held of record by the City Hill Venture Partners I, LLC except to the extent of his pecuniary interest therein. This amendment is being filed to disclose indirectly held shares that were inadvertently omitted from the original Form 4. There was no change in ownership of these indirectly held shares. /s/ Jonathan Lim 2017-12-27