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Stock Plans (Tables)
 12 Months Ended
Dec. 31, 2017
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]  
Summary of Stock Option Activity

The following table summarizes the option activity for each of the years ended December 31, 2017 and 2016 under the 2014 Plan:

 

 

Number of

Shares

 

 

Weighted-

Average Exercise

Price Per

Share

 

 

Aggregate

Intrinsic

Value

 

 

 

 

 

 

 

 

 

 

 

(in thousands)

 

Outstanding as of December 31, 2015

 

 

405,190

 

 

$

19.80

 

 

 

 

 

Granted

 

 

289,125

 

 

$

31.08

 

 

 

 

 

Exercised

 

 

(21,107

)

 

$

18.84

 

 

 

 

 

Cancelled

 

 

(7,000

)

 

$

27.16

 

 

 

 

 

Outstanding as of December 31, 2016

 

 

666,208

 

 

$

24.64

 

 

$

2,064

 

Granted

 

 

78,750

 

 

$

7.20

 

 

 

 

 

Exercised

 

 

—

 

 

 

 

 

 

 

 

 

Cancelled

 

 

(223,062

)

 

$

27.04

 

 

 

 

 

Outstanding as of December 31, 2017

 

 

521,896

 

 

$

20.96

 

 

$

255

 

Vested and exercisable as of December 31, 2017

 

 

335,230

 

 

$

20.36

 

 

$

128

 

Weighted-average years remaining on contractual life

 

 

7.80

 

 

 

 

 

 

 

 

 

Unrecognized compensation cost related to non-vested stock

   options

 

$

3,459

 

 

 

 

 

 

 

 

 

The following table summarizes stock option activity for each of the years ended December 31, 2017 and 2016 under the 2004 Plan:

 

 

Number

of Shares

 

 

Weighted-

Average Exercise Price Per

Share

 

 

Aggregate

Intrinsic

Value

 

 

 

 

 

 

 

 

 

 

 

(in thousands)

 

Outstanding as of December 31, 2015

 

 

2,729

 

 

$

162.32

 

 

 

 

 

Exercised

 

 

—

 

 

$

—

 

 

 

 

 

Expired

 

 

—

 

 

$

—

 

 

 

 

 

Cancelled

 

 

(73

)

 

$

162.32

 

 

 

 

 

Outstanding as of December 31, 2016

 

 

2,656

 

 

$

162.32

 

 

 

 

 

Exercised

 

 

—

 

 

$

—

 

 

 

 

 

Expired

 

 

(570

)

 

$

162.32

 

 

 

 

 

Cancelled

 

 

(462

)

 

$

162.32

 

 

 

 

 

Outstanding as of December 31, 2017

 

 

1,624

 

 

$

162.32

 

 

$

—

 

Vested and exercisable as of December 31, 2017

 

 

1,624

 

 

$

162.32

 

 

$

—

 

Weighted-average years remaining on contractual life

 

 

0.66

 

 

 

 

 

 

 

 

 

Unrecognized compensation cost related to non-vested stock

   options

 

$

—

 

 

 

 

 

 

 

 

 

 
Summary of RSU Activity

The following table summarizes the RSU activity for each of the years ended December 31, 2017 and 2016 under the 2014 Plan:

 

 

 

Number of

Shares

 

 

Weighted-

Average Grant Date Fair Value Per

Share

 

Outstanding as of December 31, 2015

 

 

-

 

 

 

 

 

Granted

 

 

117,500

 

 

$

26.00

 

Vested

 

 

-

 

 

 

 

 

Cancelled

 

 

-

 

 

 

 

 

Outstanding as of December 31, 2016

 

 

117,500

 

 

$

26.00

 

Granted

 

 

232,750

 

 

$

6.40

 

Vested and settled

 

 

(56,406

)

 

$

6.76

 

Cancelled

 

 

(22,125

)

 

$

6.80

 

Outstanding as of December 31, 2017

 

 

271,719

 

 

$

4.20

 

 
Schedule of Stock-Based Compensation Expense

Stock-based compensation expense for options, RSUs and the ESPP is reflected in the consolidated statements of operations as follows:

 

 

December 31,

 

 

 

2017

 

 

2016

 

 

 

(in thousands)

 

Research and development

 

$

1,287

 

 

$

1,362

 

General and administrative

 

 

2,749

 

 

 

1,547

 

Total

 

$

4,036

 

 

$

2,909