Stock Based Compensation, Stock-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Stock-Based Compensation Expense [Abstract]
Total share based compensation expense	$ 7,677	$ 6,989	$ 21,316	$ 22,200
Weighted average period expected to recognize unrecognized share-based compensation cost			2 years 18 days
Research and Development [Member]
Stock-Based Compensation Expense [Abstract]
Total share based compensation expense	3,040	3,084	$ 8,247	9,148
General and Administrative [Member]
Stock-Based Compensation Expense [Abstract]
Total share based compensation expense	4,637	3,905	13,069	13,052
Stock Options [Member]
Stock-Based Compensation Expense [Abstract]
Total share based compensation expense	6,694	6,831	19,332	21,872
Unrecognized share-based compensation cost	50,100		50,100
Restricted Stock Units [Member]
Stock-Based Compensation Expense [Abstract]
Total share based compensation expense	983	$ 158	1,984	$ 328
Unrecognized share-based compensation cost	$ 50,100		$ 50,100