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Commitments and Contingencies, Operating Leases (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Mar. 26, 2021
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Jun. 07, 2018
Operating Leases [Abstract]              
Rent expense   $ 300 $ 300 $ 600 $ 500    
Restricted cash   $ 1,334   $ 1,334   $ 1,568  
ESB Lease Agreement [Member]              
Operating Leases [Abstract]              
Term of lease agreement   3 years   3 years      
Letter of credit             $ 900
Lease expiration date       Aug. 29, 2024      
Certificate of deposit   $ 800   $ 800   900  
ESB Lease Agreement Amendment [Member]              
Operating Leases [Abstract]              
Letter of credit   800   $ 800      
Lease expiration date Jun. 30, 2024            
Operating lease right of use asset, adjustment $ 1,100            
Inotek Lexington Massachusetts Lease Agreement [Member]              
Operating Leases [Abstract]              
Lease expiration date       Feb. 28, 2023      
Rental income received under sublease agreement   100 $ 100 $ 200 $ 200    
Operating and Finance Leases [Member]              
Operating Leases [Abstract]              
Restricted cash   $ 1,000   $ 1,000   $ 1,100