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Commitments and Contingencies, Operating Leases (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 26, 2021
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Jun. 07, 2018
Operating Leases [Abstract]          
Rent expense   $ 300 $ 300    
Restricted cash   $ 1,461   $ 1,568  
ESB Lease Agreement [Member]          
Operating Leases [Abstract]          
Term of lease agreement   3 years      
Letter of credit         $ 900
Letter of credit expiration date   Jun. 30, 2020      
LOC automatic renewal period   1 year      
Lease expiration date   Jul. 31, 2021      
Certificate of deposit   $ 800   900  
ESB Lease Agreement Amendment [Member]          
Operating Leases [Abstract]          
Letter of credit   800      
Lease expiration date Jun. 30, 2024        
Operating lease right of use asset, adjustment $ 1,100        
Certificate of deposit   $ 800      
Inotek Lexington Massachusetts Lease Agreement [Member]          
Operating Leases [Abstract]          
Lease expiration date   Feb. 28, 2023      
Rental income received under sublease agreement   $ 100 $ 100    
Operating and Finance Leases [Member]          
Operating Leases [Abstract]          
Restricted cash   $ 1,000   $ 1,100