Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating activities:
Net loss	$ (258,746)	$ (245,595)	$ (221,863)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization of property and equipment	7,221	4,944	3,932
Amortization of finance lease right of use asset	2,154	2,154	2,334
Impairment of acquired intangible asset	0	574	0
Write down of property and equipment, net	0	311	236
Stock-based compensation	43,920	39,406	31,009
Accretion of discount and amortization of premium on investments, net	(8,068)	(10,168)	134
Change in fair value of warrant liabilities	1,876	(364)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(661)	2,694	(3,593)
Accounts payable and accrued expenses	6,067	10,147	9,674
Operating lease liabilities and right of use assets, net	89	137	(120)
Finance lease liability	95	139	172
Other liabilities	(3,671)	705	(57)
Net cash used in operating activities	(209,724)	(194,916)	(178,142)
Investing activities:
Purchases of investments	(245,886)	(390,920)	(376,327)
Proceeds from maturities of investments	383,454	309,326	272,894
Cash proceeds from acquisition of business, net of cash paid	0	0	42,726
Payments made to acquire right of use asset	0	(36)	(261)
Purchases of property and equipment	(5,862)	(16,436)	(8,358)
Net cash provided by/(used in) investing activities	131,706	(98,066)	(69,326)
Financing activities:
Issuance of common stock, pursuant to exercise of stock options	3,211	2,231	631
Treasury stock repurchase	0	0	(47)
Issuance of common stock, pursuant to sale of treasury stock	0	56	0
Issuance of common stock, pursuant to exercise of warrants	0	7	0
Net cash provided by financing activities	185,739	208,401	155,288
Net change in cash, cash equivalents and restricted cash	107,721	(84,581)	(92,180)
Cash, cash equivalents and restricted cash at beginning of period	57,276	141,857	234,037
Cash, cash equivalents and restricted cash at end of period	164,997	57,276	141,857
Supplemental disclosure of non-cash financing and investing activities:
Accrued purchases of property and equipment, ending balance	185	1,077	2,095
Receivables from sale of property and equipment, ending balance	135	0	0
Operating lease liabilities	1,134	2,929	0
Operating lease right of use assets	1,134	2,958	0
Unrealized (loss) gain on investmentss	(253)	676	(196)
Issuance of common stock related to acquisition	0	0	70,724
Reclassification of construction in process from finance right of use asset	0	0	261
Public Offering
Financing activities:
Issuance of common stock, net of issuance costs	182,528	188,885	108,138
At-the-Market Offering
Financing activities:
Issuance of common stock, net of issuance costs	$ 0	$ 17,222	$ 46,566