Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Operating activities:
Net loss	$ (62,054)	$ (58,335)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization of property and equipment	1,716	1,135
Amortization of finance lease right of use asset	538	538
Stock-based compensation	10,252	8,915
Accretion of discount on investments, net	(2,754)	(2,343)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,151)	866
Accounts payable and accrued expenses	(2,413)	(7,750)
Operating lease liabilities and right of use assets, net	13	97
Finance lease liability	27	37
Other liabilities	(1,030)	(720)
Net cash used in operating activities	(56,856)	(57,560)
Investing activities:
Purchases of investments	(63,947)	(96,034)
Proceeds from maturities of investments	101,016	62,335
Payments made to acquire right of use asset	0	(7)
Purchases of property and equipment	(2,035)	(3,015)
Net cash provided by (used in) investing activities	35,034	(36,721)
Financing activities:
Issuance of common stock, pursuant to exercise of stock options	1,184	1,114
Issuance of common stock pursuant to the at-the-market offering program, net of issuance costs	0	17,222
Issuance of common stock, pursuant to exercise of warrants	0	7
Net cash provided by financing activities	1,184	18,343
Net change in cash, cash equivalents and restricted cash	(20,638)	(75,938)
Cash, cash equivalents and restricted cash at beginning of period	57,276	141,857
Cash, cash equivalents and restricted cash at end of period	36,638	65,919
Supplemental disclosure of non-cash financing and investing activities:
Accrued purchases of property and equipment, ending balance	923	1,794
Investment maturity receivables and purchase payables, ending balance	8,648	0
Operating lease liabilities	1,134	0
Unrealized loss on investments	$ (454)	$ 267