X0303 4 2010-01-11 0001322505 Biodel Inc BIOD 0001397513 KROIN DAVID C/O BIODEL INC 100 SAW MILL ROAD DANBURY CT 06810 1 0 0 0 0001281446 GREAT POINT PARTNERS LLC 165 MASON STREET 3RD FLOOR GREENWICH CT 06830 1 0 0 0 Common Stock 2010-01-11 4 S 0 35200 5.01 D 1126443 D Common Stock 2010-01-12 4 S 0 34010 5.06 D 1092433 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 19, 2009. This transaction was executed in multiple trades at prices ranging from $5.00 to 5.08. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $5.00 to 5.18. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The amount shown represents the beneficial ownership of the issuer's securities by Great Point Partners I, L.P., which may be deemed attributable to Mr. Kroin because Mr. Kroin is a co-founder and managing director of Great Point Partners I, L.P. Mr. Kroin serves as a director of the issuer as a representative of Great Point Partners I, L.P., and accordingly Great Point Partners I, L.P. may be deemed to be a director by deputization. Mr. Kroin disclaims beneficial ownership of the shares except to the extent of his pecuinary interest therein. /s/Paul Bavier Attorney-in-fact 2010-01-13 /s/ David Kroin, Managing Member of Great Point Partners I GP, LLC 2010-01-13