The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 16,248 | 942,445 | SH | DFND | 1,2 | 942,445 | 0 | 0 | |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | 3,630 | 928,282 | SH | DFND | 1,2 | 928,282 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 17,318 | 700,000 | SH | DFND | 1,2 | 700,000 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 5,095 | 4,761,905 | SH | DFND | 1,2 | 4,761,905 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 9,235 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 24,160 | 550,592 | SH | DFND | 1,2 | 550,592 | 0 | 0 | |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | 23,291 | 1,423,682 | SH | DFND | 1,2 | 1,423,682 | 0 | 0 | |
| CINCOR PHARMA INC | COM | 17240Y109 | 1,397 | 79,670 | SH | DFND | 1,2 | 79,670 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 23,927 | 650,000 | SH | DFND | 1,2 | 650,000 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 29,471 | 1,300,000 | SH | DFND | 1,2 | 1,300,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 22,327 | 360,000 | SH | DFND | 1,2 | 360,000 | 0 | 0 | |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 24,129 | 155,000 | SH | DFND | 1,2 | 155,000 | 0 | 0 | |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 12,886 | 874,197 | SH | DFND | 1,2 | 874,197 | 0 | 0 | |
| KINIKSA PHARMACEUTICALS LTD | COM CL A | G5269C101 | 11,114 | 1,118,067 | SH | DFND | 1,2 | 1,118,067 | 0 | 0 | |
| MAGENTA THERAPEUTICS INC | COM | 55910K108 | 3,393 | 1,170,000 | SH | DFND | 1,2 | 1,170,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 539 | 100,000 | SH | Call | DFND | 1,2 | 100,000 | 0 | 0 |
| PASSAGE BIO INC | COM | 702712100 | 353 | 113,900 | SH | DFND | 1,2 | 113,900 | 0 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 6,663 | 2,199,076 | SH | DFND | 1,2 | 2,199,076 | 0 | 0 | |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 16,418 | 2,060,000 | SH | DFND | 1,2 | 2,060,000 | 0 | 0 | |
| RAFAEL HLDGS INC | COM CL B | 75062E106 | 304 | 121,000 | SH | DFND | 1,2 | 121,000 | 0 | 0 | |
| RELMADA THERAPEUTICS INC | COM | 75955J402 | 21,322 | 790,000 | SH | DFND | 1,2 | 790,000 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 11,960 | 4,000,000 | SH | DFND | 1,2 | 4,000,000 | 0 | 0 | |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 8,444 | 444,443 | SH | DFND | 1,2 | 444,443 | 0 | 0 | |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | 26,028 | 1,010,000 | SH | DFND | 1,2 | 1,010,000 | 0 | 0 | |
| TRICIDA INC | COM | 89610F101 | 10,275 | 1,250,000 | SH | DFND | 1,2 | 1,250,000 | 0 | 0 | |
| UROGEN PHARMA LTD | COM | M96088105 | 7,608 | 873,424 | SH | DFND | 1,2 | 873,424 | 0 | 0 | |
| VAXCYTE INC | COM | 92243G108 | 21,376 | 885,153 | SH | DFND | 1,2 | 885,153 | 0 | 0 | |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 4,564 | 336,334 | SH | DFND | 1,2 | 336,334 | 0 | 0 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 22,182 | 85,000 | SH | DFND | 1,2 | 85,000 | 0 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 28,124 | 920,000 | SH | DFND | 1,2 | 920,000 | 0 | 0 | |