ACADIA PHARMACEUTICALS INC
COM
004225108
38518
720502
SH
DFND
1,2
720502
0
0
ARENA PHARMACEUTICALS INC
COM NEW
040047607
26516
345120
SH
DFND
1,2
345120
0
0
ARVINAS INC
COM
04335A105
13941
164150
SH
DFND
1,2
164150
0
0
AURINIA PHARMACEUTICALS INC
COM
05156V102
2420
175000
SH
DFND
1,2
175000
0
0
CALITHERA BIOSCIENCES INC
COM
13089P101
9059
1845000
SH
DFND
1,2
1845000
0
0
CALITHERA BIOSCIENCES INC
COM
13089P101
2455
500000
SH
Call
DFND
1,2
500000
0
0
COLLEGIUM PHARMACEUTICAL INC
COM
19459J104
8440
421383
SH
DFND
1,2
421383
0
0
CONSTELLATION PHARMCETICLS I
COM
210373106
29514
1024800
SH
DFND
1,2
1024800
0
0
EXELIXIS INC
COM
30161Q104
9533
475000
SH
DFND
1,2
475000
0
0
FIBROGEN INC
COM
31572Q808
6176
166500
SH
Call
DFND
1,2
166500
0
0
FORMA THERAPEUTICS HLDGS INC
SHS
34633R104
8250
236400
SH
DFND
1,2
236400
0
0
GERON CORP
COM
374163103
8038
5055189
SH
DFND
1,2
5055189
0
0
GLOBAL BLOOD THERAPEUTICS IN
COM
37890U108
25790
595473
SH
DFND
1,2
595473
0
0
GW PHARMACEUTICALS PLC
ADS
36197T103
45010
390000
SH
DFND
1,2
390000
0
0
INSULET CORP
COM
45784P101
15338
60000
SH
DFND
1,2
60000
0
0
INTERSECT ENT INC
COM
46071F103
29836
1302871
SH
DFND
1,2
1302871
0
0
IONIS PHARMACEUTICALS INC
COM
462222100
4241
75000
SH
DFND
1,2
75000
0
0
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
42569
917427
SH
DFND
1,2
917427
0
0
KADMON HLDGS INC
COM
48283N106
16948
4083909
SH
DFND
1,2
4083909
0
0
MACROGENICS INC
COM
556099109
28330
1239287
SH
DFND
1,2
1239287
0
0
MERSANA THERAPEUTICS INC
COM
59045L106
12971
487452
SH
DFND
1,2
487452
0
0
MILLENDO THERAPEUTICS INC
COM
60040X103
578
270000
SH
DFND
1,2
270000
0
0
OCULAR THERAPEUTIX INC
COM
67576A100
17723
856162
SH
DFND
1,2
856162
0
0
PROTHENA CORP PLC
SHS
G72800108
11742
977647
SH
DFND
1,2
977647
0
0
PULMONX CORP
COM
745848101
4441
64345
SH
DFND
1,2
64345
0
0
PUMA BIOTECHNOLOGY INC
COM
74587V107
13338
1300000
SH
DFND
1,2
1300000
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
38388
700000
SH
DFND
1,2
700000
0
0
SAGE THERAPEUTICS INC
COM
78667J108
39312
454417
SH
DFND
1,2
454417
0
0
SILVERBACK THERAPEUTICS INC
COM
82835W108
3244
70000
SH
DFND
1,2
70000
0
0
THERAVANCE BIOPHARMA INC
COM
G8807B106
14653
824580
SH
DFND
1,2
824580
0
0
UNITED THERAPEUTICS CORP DEL
COM
91307C102
22769
150000
SH
DFND
1,2
150000
0
0
VERICEL CORP
COM
92346J108
27792
900000
SH
DFND
1,2
900000
0
0
ZYMEWORKS INC
COM
98985W102
37795
799722
SH
DFND
1,2
799722
0
0