The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 3,971 3,892,921 SH   DFND 1,2 3,892,921 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 79,264 1,921,563 SH   DFND 1,2 1,921,563 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 12,400 328,817 SH   DFND 1,2 328,817 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 74,558 996,898 SH   DFND 1,2 996,898 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 36,609 2,485,327 SH   DFND 1,2 2,485,327 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 28,279 435,000 SH   DFND 1,2 435,000 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 10,069 2,918,581 SH   DFND 1,2 2,918,581 0 0
CHEMOCENTRYX INC COM 16383L106 13,877 253,230 SH   DFND 1,2 253,230 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 57,983 2,861,924 SH   DFND 1,2 2,861,924 0 0
CYTOKINETICS INC COM NEW 23282W605 5,477 253,000 SH Put DFND 1,2 253,000 0 0
CYTOKINETICS INC COM NEW 23282W605 55,197 2,549,525 SH   DFND 1,2 2,549,525 0 0
GERON CORP COM 374163103 16,853 9,685,528 SH   DFND 1,2 9,685,528 0 0
GLAUKOS CORP COM 377322102 22,091 446,097 SH   DFND 1,2 446,097 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 36,154 655,676 SH   DFND 1,2 655,676 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 50,645 520,232 SH   DFND 1,2 520,232 0 0
INTERSECT ENT INC COM 46071F103 12,199 747,926 SH   DFND 1,2 747,926 0 0
INVENTIVA SA ADS 46124U107 11,813 999,422 SH   DFND 1,2 999,422 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 127,618 3,876,600 SH   DFND 1,2 3,876,600 0 0
KADMON HLDGS INC COM 48283N106 9,800 2,500,000 SH   DFND 1,2 2,500,000 0 0
LANTHEUS HLDGS INC COM 516544103 7,535 594,750 SH   DFND 1,2 594,750 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 5,853 1,189,607 SH   DFND 1,2 1,189,607 0 0
MACROGENICS INC COM 556099109 38,042 1,510,215 SH   DFND 1,2 1,510,215 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 1,920 1,177,900 SH   DFND 1,2 1,177,900 0 0
OYSTER PT PHARMA INC COM 69242L106 1,480 70,121 SH   DFND 1,2 70,121 0 0
PROTHENA CORP PLC SHS G72800108 15,469 1,548,479 SH   DFND 1,2 1,548,479 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 11,120 1,102,073 SH   DFND 1,2 1,102,073 0 0
SAGE THERAPEUTICS INC COM 78667J108 120,204 1,966,688 SH   DFND 1,2 1,966,688 0 0
SANGAMO THERAPEUTICS INC COM 800677106 15,023 1,589,724 SH   DFND 1,2 1,589,724 0 0
TG THERAPEUTICS INC COM 88322Q108 42,816 1,600,000 SH   DFND 1,2 1,600,000 0 0
TRANSLATE BIO INC COM 89374L104 12,839 943,339 SH   DFND 1,2 943,339 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 64,718 640,773 SH   DFND 1,2 640,773 0 0
VERICEL CORP COM 92346J108 27,439 1,480,787 SH   DFND 1,2 1,480,787 0 0
VIEWRAY INC COM 92672L107 9,295 2,655,763 SH   DFND 1,2 2,655,763 0 0
ZYMEWORKS INC COM 98985W102 73,033 1,567,900 SH   DFND 1,2 1,567,900 0 0