The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS, INC. | COM | 004225108 | 40,095,000 | 1,500,000 | SH | DFND | 1,2 | 1,500,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 59,537,000 | 1,449,300 | SH | DFND | 1,2 | 1,449,300 | 0 | 0 | |
| ASCENDIS PHARMA AS | SPOSORED ADR | 04351P101 | 57,575,000 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
| DERMIRA INC. | COM | 24983L104 | 14,846,000 | 1,552,900 | SH | DFND | 1,2 | 1,552,900 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS, INC. | COM | 33830X104 | 3,303,000 | 547,712 | SH | DFND | 1,2 | 547,712 | 0 | 0 | |
| GENFIT | ADS | 372279109 | 13,711,000 | 694,253 | SH | DFND | 1,2 | 694,253 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS, INC. | COM | 462260100 | 128,995,000 | 5,260,803 | SH | DFND | 1,2 | 5,260,803 | 0 | 0 | |
| IOVANCE BIOTHERAPETUICS, INC. | COM | 462260100 | 4,904,000 | 200,000 | SH | Call | DFND | 1,2 | 200,000 | 0 | 0 |
| KURA ONCOLOGY, INC. | COM | 50127T109 | 60,011,000 | 3,047,800 | SH | DFND | 1,2 | 3,047,800 | 0 | 0 | |
| MENLO THERAPEUTICS INC. | COM | 586858102 | 10,386,000 | 1,733,882 | SH | DFND | 1,2 | 1,733,882 | 0 | 0 | |
| MILLENDO THERAPEUTICS, INC. | COM | 60040X103 | 14,891,000 | 1,288,093 | SH | DFND | 1,2 | 1,288,093 | 0 | 0 | |
| MIRATI THERAPEUTICS INC. | COM | 60468T105 | 30,900,000 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC. | COM | 60468T105 | 10,300,000 | 100,000 | SH | Put | DFND | 1,2 | 100,000 | 0 | 0 |
| MIRATI THERAPEUTICS INC. | COM | 60468T105 | 20,600,000 | 200,000 | SH | Put | DFND | 1,2 | 200,000 | 0 | 0 |
| MIRATII THERAPEUTICS INC. | COM | 60468T105 | 18,025,000 | 175,000 | SH | Call | DFND | 1,2 | 175,000 | 0 | 0 |
| MOMENTA PHARMACEUTICALS, INC. | COM | 60877T100 | 4,259,000 | 342,064 | SH | DFND | 1,2 | 342,064 | 0 | 0 | |
| PTC THERAPEUTICS, INC. | COM | 69366J200 | 88,847,000 | 1,974,385 | SH | DFND | 1,2 | 1,974,385 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS INC. | COM | 74373B109 | 3,416,000 | 3,500,000 | SH | DFND | 1,2 | 3,500,000 | 0 | 0 | |
| RETROPHIN INC. | COM | 761299106 | 20,162,000 | 1,003,600 | SH | DFND | 1,2 | 1,003,600 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTNS, INC. | COM | 86323X106 | 197,000 | 130,137 | SH | DFND | 1,2 | 130,137 | 0 | 0 | |
| ZAFGEN INC. | COM | 98885E103 | 2,631,000 | 2,211,194 | SH | DFND | 1,2 | 2,211,194 | 0 | 0 | |
| ZOGENIX, INC. | COM | 98978L204 | 76,132,000 | 1,593,396 | SH | DFND | 1,2 | 1,593,396 | 0 | 0 | |
| ZOGENIX, INC. | COM | 98978L204 | 14,334,000 | 300,000 | SH | Put | DFND | 1,2 | 300,000 | 0 | 0 |
| ZYMEWORKS INC. | COM | 98985W102 | 23,409,000 | 1,064,041 | SH | DFND | 1,2 | 1,064,041 | 0 | 0 | |
| BIOHAVEN PHARMACEUTICAL HOLDING CO LTD. | COM | G11196105 | 15,327,000 | 350,000 | SH | DFND | 1,2 | 350,000 | 0 | 0 | |
| BIOHAVEN PHARMACEUTICAL HOLDING CO. LTD. | COM | G11196105 | 8,758,000 | 200,000 | SH | Put | DFND | 1,2 | 200,000 | 0 | 0 |
| OSMOTICA PHARMACEUTICALS PLC | COM | G6S41R101 | 3,522,000 | 926,933 | SH | DFND | 1,2 | 926,933 | 0 | 0 | |
| PROTHENA CORPORATION PLC | COM | G72800108 | 17,718,000 | 1,676,250 | SH | DFND | 1,2 | 1,676,250 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | COM | M46135105 | 5,022,000 | 2,110,071 | SH | DFND | 1,2 | 2,110,071 | 0 | 0 | |
| AUDENTES THERAPEUTICS, INC. | COM | 05070R104 | 72,802,000 | 1,922,937 | SH | DFND | 1,2 | 1,922,937 | 0 | 0 | |
| TRICIDA, INC. | COM | 89610F101 | 56,191,000 | 1,423,998 | SH | DFND | 1,2 | 1,423,998 | 0 | 0 | |