The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 18,074,000 462,245 SH   DFND 1,2 462,245 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 13,727,000 3,700,000 SH   DFND 1,2 3,700,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 4,730,000 200,000 SH Put DFND 1,2 200,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 449,000 19,000 SH Call DFND 1,2 19,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 28,665,000 900,579 SH   DFND 1,2 900,579 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 3,181,000 1,056,825 SH   DFND 1,2 1,056,825 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 1,795,000 596,200 SH Call DFND 1,2 596,200 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 1,505,000 500,000 SH Call DFND 1,2 500,000 0 0
ANTARES PHARMA INC COM 036642106 1,100,000 500,000 SH   DFND 1,2 500,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 51,583,000 1,305,887 SH   DFND 1,2 1,305,887 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 604,000 15,300 SH Call DFND 1,2 15,300 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 35,671,000 7,478,275 SH   DFND 1,2 7,478,275 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 6,579,000 1,687,020 SH   DFND 1,2 1,687,020 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 6,443,000 2,695,742 SH   DFND 1,2 2,695,742 0 0
CORSICANTO II DESIGNATED ACT NOTE 220485AB2 11,025,000 10,000,000 SH   DFND 1,2 10,000,000 0 0
ENDOCYTE INC COM 29269A102 13,558,000 1,491,500 SH   DFND 1,2 1,491,500 0 0
EXELIXIS INC COM 30161Q104 19,933,000 899,900 SH   DFND 1,2 899,900 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 14,914,000 868,100 SH   DFND 1,2 868,100 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 35,579,000 736,631 SH   DFND 1,2 736,631 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 275,000 5,700 SH Put DFND 1,2 5,700 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 56,128,000 3,321,173 SH   DFND 1,2 3,321,173 0 0
KURA ONCOLOGY INC COM 50127T109 44,641,000 2,380,846 SH   DFND 1,2 2,380,846 0 0
MENLO THERAPEUTICS INC COM 586858102 1,954,000 52,008 SH   DFND 1,2 52,008 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 33,172,000 400,000 SH   DFND 1,2 400,000 0 0
NEWLINK GENETICS CORP COM 651511107 1,693,000 233,500 SH   DFND 1,2 233,500 0 0
PTC THERAPEUTICS INC COM 69366J200 41,668,000 1,539,822 SH   DFND 1,2 1,539,822 0 0
PTC THERAPEUTICS INC COM 69366J200 5,412,000 200,000 SH Call DFND 1,2 200,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 34,025,000 500,000 SH   DFND 1,2 500,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 30,371,000 8,579,454 SH   DFND 1,2 8,579,454 0 0
SAVARA INC COM 805111101 7,932,000 862,179 SH   DFND 1,2 862,179 0 0
SIERRA ONCOLOGY INC COM 82640U107 6,440,000 3,111,111 SH   DFND 1,2 3,111,111 0 0
SPARK THERAPEUTICS INC COM 84652J103 36,625,000 550,000 SH   DFND 1,2 550,000 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 239,000 130,137 SH   DFND 1,2 130,137 0 0
VANDA PHARMACEUTICALS INC COM 921659108 5,220,000 309,800 SH   DFND 1,2 309,800 0 0
ZOGENIX INC COM NEW 98978L204 39,181,000 978,302 SH   DFND 1,2 978,302 0 0
NOVOCURE LTD ORD SHS G6674U108 16,426,000 753,481 SH   DFND 1,2 753,481 0 0
PROTHENA CORP PLC SHS G72800108 18,355,000 500,000 SH Call DFND 1,2 500,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 24,530,000 4,781,708 SH   DFND 1,2 4,781,708 0 0