The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 14,997 493,500 SH   DFND 1,2 493,500 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 38,764 2,216,351 SH   DFND 1,2 2,216,351 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 8,952 435,402 SH   DFND 1,2 435,402 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 22,078 276,800 SH   DFND 1,2 276,800 0 0
AMARIN CORPORATION PLC SPONS ADR NEW 023111206 7,133 1,770,000 SH   DFND 1,2 1,770,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 125 12,400 SH Call DFND 1,2 12,400 0 0
ARADIGM CORP COM PAR 038505400 835 637,279 SH   DFND 1,2 637,279 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 41,162 2,439,930 SH   DFND 1,2 2,439,930 0 0
BOVIE MEDICAL CORP COM 10211F100 7,222 2,924,015 SH   DFND 1,2 2,924,015 0 0
CARA THERAPEUTICS INC COM 140755109 761 49,471 SH   DFND 1,2 49,471 0 0
CARA THERAPEUTICS INC COM 140755109 71 4,600 SH Put DFND 1,2 4,600 0 0
CARA THERAPEUTICS INC COM 140755109 3,980 258,600 SH Put DFND 1,2 258,600 0 0
CARA THERAPEUTICS INC COM 140755109 126 8,200 SH Put DFND 1,2 8,200 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 27,900 2,000,000 SH   DFND 1,2 2,000,000 0 0
DBV TECHNOLOGIES SA SPONSORED ADR 23306J101 17,855 500,000 SH   DFND 1,2 500,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 4,203 435,500 SH   DFND 1,2 435,500 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 6,985 255,400 SH   DFND 1,2 255,400 0 0
IGNYTA INC COM 451731103 18,105 1,749,323 SH   DFND 1,2 1,749,323 0 0
INSMED INC COM PAR 457669307 9,240 538,473 SH   DFND 1,2 538,473 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1,242 169,014 SH   DFND 1,2 169,014 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 27,600 600,000 SH   DFND 1,2 600,000 0 0
NEWLINK GENETICS CORP COM 651511107 8,032 1,092,849 SH   DFND 1,2 1,092,849 0 0
PTC THERAPEUTICS INC COM 69366J200 34,827 1,900,000 SH   DFND 1,2 1,900,000 0 0
PTC THERAPEUTICS INC COM 69366J200 4,766 260,000 SH Call DFND 1,2 260,000 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 14,310 300,000 SH   DFND 1,2 300,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 8,426 150,000 SH Call DFND 1,2 150,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 3,718 66,200 SH Call DFND 1,2 66,200 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 24,859 9,105,691 SH   DFND 1,2 9,105,691 0 0
SAGE THERAPEUTICS INC COM 78667J108 19,416 243,800 SH   DFND 1,2 243,800 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,109 51,600 SH Put DFND 1,2 51,600 0 0
SEATTLE GENETICS INC COM 812578102 12,909 249,500 SH Call DFND 1,2 249,500 0 0
SELECTA BIOSCIENCES INC COM 816212104 18,619 937,500 SH   DFND 1,2 937,500 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 139 130,137 SH   DFND 1,2 130,137 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 3,864 1,431,149 SH   DFND 1,2 1,431,149 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 32,145 7,223,509 SH   DFND 1,2 7,223,509 0 0
VANDA PHARMACEUTICALS INC COM 921659108 36,385 2,232,238 SH   DFND 1,2 2,232,238 0 0
ZOGENIX INC COM NEW 98978L204 35,394 2,440,959 SH   DFND 1,2 2,440,959 0 0
MYOVANT SCIENCES LTD COM G637AM102 2,900 247,899 SH   DFND 1,2 247,899 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 22,187 4,781,708 SH   DFND 1,2 4,781,708 0 0
NEURODERM LTD ORD SHS M74231107 9,299 311,000 SH   DFND 1,2 311,000 0 0
CONNECTURE INC COM 20786J106 2,550 4,127,232 SH   DFND 1,2 4,127,232 0 0