X0306 4 2016-05-25 0 0001123494 HARVARD BIOSCIENCE INC HBIO 0001281069 HARTE NEAL J UNIT # 1 83 CHURCH STREET WINCHESTER MA 01890 1 0 0 0 Common Stock 2016-05-25 4 M 0 6589 3.01 A 106399 D Stock option (right to buy) 3.01 2016-05-25 4 M 0 6589 0.00 D 2009-05-25 2016-05-25 Common Stock, par value $0.01 per share 6589 0 D Includes (a) a deferred stock award of 14,400 restricted stock units which fully vest on the earlier of (i) the date of the Issuer's next Annual Meeting of Stockholders after June 4, 2015, immediately prior to the commencement of such meeting, and (ii) June 4, 2016; (b) a deferred stock award of 10,800 restricted stock units which vest quarterly in equal installments on June 30, 2016, September 30, 2016 and December 31, 2016; and (c) 81,199 shares of common stock held by the Reporting Person. Represent the exercise of stock options granted pursuant to the Issuer's 2000 Stock Option and Incentive Plan, as amended. This form has been signed under power of attorney. /s/ Chad Porter, by power of attorney 2016-05-26