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Stock Compensation Plans - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Jan. 03, 2018
Apr. 16, 2017
Oct. 31, 2015
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Nov. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options expiration period       10 years      
Options outstanding (in shares)       6,083,482 4,841,274    
Weighted-average grant date fair value of stock options granted to employees and directors (usd per share)       $ 2.34 $ 5.70 $ 5.81  
Non-Employees              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Compensation cost related to unvested stock option awards       $ 449      
2014 Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Shares of common stock for annual increase in shares available for issuance (in shares)       1,200,000      
Percent of outstanding shares of common stock prior to each anniversary       3.00%      
Number of additional shares authorized (in shares)   1,200,000          
Aggregate number of shares outstanding or available for grant under the plan (in shares)       125,000      
2014 Equity Incentive Plan | Performance-Based Employee Stock Options              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options expiration period       10 years      
Options outstanding (in shares)       647,322      
Option vesting under Equity Incentive Plans, term     3 years        
Options exercise price, minimum (usd per share)       $ 4.57      
Options exercise price, maximum (usd per share)       $ 7.69      
Amended and Restated 2017 Inducement Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Aggregate number of shares outstanding or available for grant under the plan (in shares)             1,850,000
Employee              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Compensation cost related to unvested stock option awards       $ 6,200      
Remaining weighted-average vesting period       1 year 8 months 12 days      
Non-Employees              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Remaining weighted-average vesting period       2 years 1 month 6 days      
Subsequent Event | Non-Employees              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Compensation cost related to unvested stock option awards $ 1,300            
Subsequent Event | Employee              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Compensation cost related to unvested stock option awards $ 12,700            
Remaining weighted-average vesting period 2 years 8 months 12 days            
Subsequent Event | Non-Employees              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Remaining weighted-average vesting period 2 years            
Minimum | 2014 Plan and 2012 Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Option vesting under Equity Incentive Plans, term       1 year      
Maximum | 2014 Plan and 2012 Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Option vesting under Equity Incentive Plans, term       4 years