X0306 5 2018-12-31 0 0 0 0001623613 Mylan N.V. MYL 0001280753 BRESCH HEATHER M BUILDING 4, TRIDENT PLACE, MOSQUITO WAY HATFIELD, HERTFORDSHIRE X0 AL10 9UL UNITED KINGDOM 1 1 0 0 Chief Executive Officer Ordinary Shares 2018-06-13 5 G 0 200 0.00 D 705507 D Ordinary Shares 1157 I By 401(k) Plan Ordinary Shares 115178 I By Grantor Retained Annuity Trust 82,231 ordinary shares were returned to the reporting person's direct beneficial ownership on June 13, 2018 in the form of a scheduled annuity payment under the terms of the grantor retained annuity trust to which the reporting person initially contributed 200,000 ordinary shares on May 6, 2016. 84,822 ordinary shares were returned to the reporting person's direct beneficial ownership on November 30, 2018 in the form of a scheduled annuity payment under the terms of the grantor retained annuity trust to which the reporting person initially contributed 200,000 ordinary shares on August 23, 2017. /s/ Kevin D. Macikowski, by Power of Attorney 2019-02-14